Kinetics of 76Br-labeled anti-CEA antibodies in pigs; aspects of dosimetry and PET imaging properties.
Kinetics of 76Br-labeled anti-CEA antibodies in pigs; aspects of dosimetry and PET imaging properties.
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76Br标记的抗CEA抗体在猪体内的动力学；
DOI：
10.1118/1.598512
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发表时间：
1999
期刊：
影响因子：
3.8
通讯作者：
A. Sundin
中科院分区：
文献类型：
--
作者：
A. Lövqvist;H. Lundqvist;M. Lubberink;V. Tolmachev;J. Carlsson;A. Sundin
用正电子发射放射性核素76Br （T(1/2) 16.2 h）标记的单克隆抗体先前已被证明可用于实验性肿瘤的正电子发射断层扫描（PET）成像。在本研究中，我们的目的是研究这种放射性核素的复杂衰变方案对正常器官剂量学和PET图像质量的影响。将3头小型猪静脉注射46-75 MBq 76br标记的抗cea抗体38S1，并进行全身动力学分析，然后进行PET成像19小时。根据PET数据，使用MIRDOSE 3.0软件估计人体器官吸收剂量。对肺内空气量进行校正后，发现肺内76Br浓度最高。肺部吸收剂量最高（mGy/MBq，平均+/-最大误差）为0.84+/-0.16，其次为肝脏0.74+/-0.28，小肠0.55+/-0.05，有效当量剂量为0.41+/-0.03 mSv/MBq。研究了76Br在二维PET相机中的成像特性，包括中心区域分辨率和散射效应，并与18F进行了比较。在0.97 g/cm3近似软组织密度的材料中，76Br点扩散函数的FMHW（“半最大全宽度”）值为7.7+/-0.2 mm， 18F为6.0+/-0.1 mm。总之，使用76br标记抗体的放射免疫PET导致辐射剂量分布相当均匀，其中器官吸收的最高剂量仅比平均吸收剂量高约2至3倍。76Br衰变中的高能β +谱对分辨率的影响很小，但可能会降低定量精度，特别是在密度较低的器官，如肺。
A monoclonal antibody labeled with the positron-emitting radionuclide 76Br (T(1/2) 16.2 h) has previously been shown useful for positron emission tomography (PET) imaging of experimental tumors. Our aim in the present study was to investigate the effects of the complex decay scheme of this radionuclide on normal organ dosimetry and PET image quality. Three mini-pigs were injected intravenously with 46-75 MBq of the 76Br-labeled anti-CEA antibody 38S1, and the whole-body kinetics followed by PET imaging for 19 h. From PET data, absorbed doses in human organs were estimated using the MIRDOSE 3.0 software. The highest 76Br concentrations were found in lungs, after a correction for the air volume in this organ. The lungs received the highest absorbed dose (mGy/MBq, mean+/-maximum error), 0.84+/-0.16, followed by liver, 0.74+/-0.28, and small intestine, 0.55+/-0.05, while the effective dose equivalent was 0.41+/-0.03 mSv/MBq. The PET imaging properties of 76Br in a two-dimensional 2D PET camera, including central area resolution and scattering effects, were investigated in phantoms and compared to those of 18F. In a 0.97 g/cm3 material, approximating soft tissue density, the FMHW ("full width at half-maximum") value of the point spread function was 7.7+/-0.2 mm for 76Br and 6.0+/-0.1 mm for 18F. In conclusion, radioimmuno PET using 76Br-labeled antibodies resulted in a fairly even distribution of the radiation dose, where the highest absorbed organ doses were only about two to three times higher than the mean absorbed body dose. The high energy beta+ spectrum in the 76Br decay had only minor effects on the resolution, but may decrease the quantification accuracy, especially in organs with a lower density such as a lung.
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通过躯干 PET 成像确定铜 64 标记单克隆抗体 1A3 的剂量测定。
DOI：
--
发表时间：
1995
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Cutler,PD;Schwarz,SW;Anderson,CJ;Connett,JM;Welch,MJ;Philpott,GW;Siegel,BA
通讯作者：
Siegel,BA
131I 标记抗癌胚抗原单克隆抗体的肿瘤、红骨髓和器官剂量测定。
影响因子：
11.2
作者：
Siegel,JA;Pawlyk,DA;Lee,RE;Sasso,NL;Horowitz,JA;Sharkey,RM;Goldenberg,DM
通讯作者：
Goldenberg,DM
DOI：
--
发表时间：
1995-10
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
G. Philpott;S. Schwarz;C. Anderson;F. Dehdashti;J. Connett;K. Zinn;C. Meares;P. Cutler;M. Welch;B. Siegel
通讯作者：
G. Philpott;S. Schwarz;C. Anderson;F. Dehdashti;J. Connett;K. Zinn;C. Meares;P. Cutler;M. Welch;B. Siegel
影响因子：
158.5
作者：
MACH, JP;CARREL, S;ALBERTO, P
通讯作者：
ALBERTO, P
影响因子：
5.8
作者：
Buehler, P.;Wolf, P.;Gierschner, D.;Schaber, I.;Katzenwadel, A.;Schultze-Seemann, W.;Wetterauer, U.;Tacke, M.;Swamy, M.;Schamel, W. W. A.;Elsaesser-Beile, U.
通讯作者：
Elsaesser-Beile, U.