Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
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DOI：
10.1002/mc.20588
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发表时间：
2010-02
影响因子：
4.6
通讯作者：
Wu, Xifeng
中科院分区：
文献类型：
--
作者：
Clague, Jessica;Lippman, Scott M.;Yang, Hushan;Hildebrandt, Michelle A. T.;Ye, Yuanqing;Lee, J. Jack;Wu, Xifeng
据报道，微小RNA（miRNAs）在肿瘤发生中起关键作用，最近，研究已经检查了miRNAs在癌前病变风险中可能起的作用。据我们所知，目前还没有研究探讨miRNA多态性与口腔癌前病变（OPL）风险之间的关系。我们在一项病例对照研究中对21个miRNA相关基因中的31个单核苷酸多态性（SNP）进行了基因分型，该研究包括136名OPL患者和136名匹配的对照。携带至少一个mir 26 a-1：rs7372209变异等位基因的患者发生OPL的风险显著增加（OR，2.09; 95%CI，1.23-3.56）。同样，至少有一个DICER：rs3742330变异等位基因的患者发生OPL的风险显著增加（OR，2.09; 95%CI，1.03-4.24）。为了评估累积效应，我们进行了一项组合的不利基因型分析，其中包括至少显示出临界统计学显著性的所有SNP。随着不利基因型数量的增加，观察到OPL风险增加的显著趋势（趋势P <0.0001）。这项研究提出了第一个流行病学证据，支持miRNA相关变异体的个体以及组合基因型可用于预测OPL的风险，并可能有助于识别OPL患者进展为口腔癌的高风险。
MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis and, recently, studies have examined the role miRNAs might play in the risk of premalignant lesions. To our knowledge, no study has investigated the association between miRNA polymorphisms and risk of oral premalignant lesions (OPL). We genotyped 31 single nucleotide polymorphisms (SNPs) among 21 miRNA-related genes in a case-control study including 136 OPL patients and 136 matched controls. Patients with at least one variant allele of mir26a-1:rs7372209 had a significantly increased risk of OPL (OR, 2.09; 95% CI, 1.23–3.56). Likewise, patients with at least one variant allele of DICER:rs3742330 had a significantly increased risk of OPL (OR, 2.09; 95% CI, 1.03–4.24). To assess the cumulative effects, we performed a combined unfavorable genotype analysis that included all SNPs showing at least a borderline statistical significance. A significant trend of increased risk of OPL with increasing number of unfavorable genotypes was observed (P for trend <0.0001). This study presents the first epidemiologic evidence supporting that individual as well as combined genotypes of miRNA-related variants may be used to predict the risk of OPL, and may be useful for identifying patients with OPL at high risk for progression to oral cancer.
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影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
DOI：
10.1073/pnas.0508947102
发表时间：
2005-11-29
影响因子：
11.1
作者：
Shpargel, KB;Matera, AG
通讯作者：
Matera, AG
影响因子：
10.5
作者：
Mourelatos, Z;Dostie, J;Dreyfuss, G
通讯作者：
Dreyfuss, G
影响因子：
5.7
作者：
Karube, Y;Tanaka, H;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
64.5
作者：
Han, Jinju;Lee, Yoontae;Kim, V. Narry
通讯作者：
Kim, V. Narry