Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.
Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.
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DOI：
10.1111/j.1748-1716.2010.02091.x
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Fredholm BB
中科院分区：
文献类型：
--
作者：
Yang JN;Wang Y;Garcia-Roves PM;Björnholm M;Fredholm BB
我们想研究缺乏腺苷A3受体（A3 R）的小鼠的表型。我们连续几天通过遥测技术检查心率、体温和运动。此外，检查了腺苷类似物R-N6-苯基异丙基-腺苷（R-PIA）的作用。此外，我们还检查了热量产生和食物摄入。我们发现，在活动，心率和体温的显着昼夜变化，在夜间明显高于白天的时间，减少了A3 R基因敲除小鼠。令人惊讶的是，在野生型小鼠中注射R-PIA后观察到的心率、活动和体温的降低在A3 R敲除小鼠中几乎被消除。正如预期的那样，活动的显著减少与产热减少有关。然而，令人惊讶的是，与野生型小鼠相比，A3 R敲除小鼠具有更高的食物摄入量，但体重没有差异。缺乏腺苷A3受体的小鼠表现出令人惊讶的明显表型，例如昼夜节律和温度调节的变化。这些效应是否是由于A3受体在这些过程中的生理作用，或者它们是否代表了发育中的作用，仍有待阐明。
We wanted to examine the phenotype of mice that lack the adenosine A3 receptor (A3R). We examined the heart rate, body temperature and locomotion continuously by telemetry over several days. In addition the effect of the adenosine analogue R - N6- phenylisopropyl-adenosine (R-PIA) was examined. In addition, we examined heat production and food intake. We found that the marked diurnal variation in activity, heart rate and body temperature, with markedly higher values at night than during day time, was reduced in the A3R knockout mice. Surprisingly, the reduction in heart rate, activity and body temperature seen after injection of R-PIA in wild type mice was virtually eliminated in the A3R knock-out mice. The marked reduction in activity was associated with a decreased heat production, as expected. However, the A3R knock-out mice, surprisingly, had a higher food intake but no difference in body weight compared to wild type mice. The mice lacking adenosine A3 receptors exhibit a surprisingly clear phenotype with changes in e.g. diurnal rhythm and temperature regulation. Whether these effects are due to a physiological role of A3 receptors in these processes or if they represent a role in development remains to be elucidated.
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影响因子：
4.7
作者：
Hammarberg, C;Schulte, G;Fredholm, BB
通讯作者：
Fredholm, BB
影响因子：
--
作者：
Borea, P A;Gessi, S;Fishman, P
通讯作者：
Fishman, P
DOI：
10.1073/pnas.161292398
发表时间：
2001-07-31
影响因子：
11.1
作者：
Johansson, B;Halldner, L;Fredholm, BB
通讯作者：
Fredholm, BB
影响因子：
4.2
作者：
Chen, Guann-Juh;Harvey, Brandon K.;Wang, Yun
通讯作者：
Wang, Yun
影响因子：
4
作者：
Fedorova, IM;Jacobson, MA;Jacobson, KA
通讯作者：
Jacobson, KA