Noninvasive measurement of blood glucose concentrations by analysing fourier transform infra-red absorbance spectra through oral mucosa
Noninvasive measurement of blood glucose concentrations by analysing fourier transform infra-red absorbance spectra through oral mucosa
复制标题
通过分析口腔粘膜的傅里叶变换红外吸收光谱来无创测量血糖浓度
DOI：
--
复制
发表时间：
1993
影响因子：
3.2
通讯作者：
Motoaki Shichiri
中科院分区：
文献类型：
--
作者：
K. Kajiwara;T. Uemura;Hideki Kishikawa;K. Nishida;Y. Hashiguchi;M. Uehara;M. Sakakida;K. Ichinose;Motoaki Shichiri
评价傅里叶变换红外光谱衰减全反射棱镜法在口腔粘膜无创血糖测量中的应用价值。结果表明，在1033 cm−1处的吸光度峰与葡萄糖水溶液中的吸光度峰相同。然而，由于棱镜附着和来自非葡萄糖的身体成分的背景光谱，这些葡萄糖特异性峰受到基线漂移的干扰。因此，为了消除这些干扰，计算了1033 cm−1处吸光度峰二阶导数与2920 cm−1处吸光度峰二阶导数之间的校准曲线（r=0·910）。利用该校准曲线，首先消除了棱镜附着引起的光谱变化。其次，通过获得餐后吸收峰与空腹样品之间差异的二阶导数作为个体的特征，观察到在1033 cm−1处通过嘴唇粘膜的吸收光谱的校正二阶导数与高于空腹水平的血糖浓度升高之间存在高度相关性（r= 0.10）。综上所述，傅里叶变换红外光谱技术可用于口腔粘膜葡萄糖的无创监测。
Whether Fourier transform infra-red spectroscopy with an attenuated total reflection prism could be applied for noninvasive glucose measurement through oral mucosa was evaluated. As a result, the same absorbance peak at 1033 cm−1 as in glucose aqueous solution was found in the absorbance spectra through mucous membrane. However, these glucose specific peaks were interfered with by the baseline drifts owing to prism attachment and the background spectra from body constituents other than glucose. Therefore, to eliminate these interferences, the calibration curve between the second derivatives of the absorbance peak at 1033 cm−1 and those at 2920 cm−1 was calculated (r=0·910). By using this calibration curve, the spectral changes due to prism attachment were first eliminated. Secondly, by obtaining the second derivative of the difference between the postprandial absorbance peak and the fasting sample as a characteristic of an individual, high correlations between the corrected second derivatives of absorbance spectra through the mucous membrane of the lip at 1033 cm−1 and the increases in blood glucose concentrations above fasting levels were observed (r=0·910). In conclusion, it was suggested that Fourier transform infra-red spectroscopy could be useful for noninvasive monitoring of glucose through oral mucosa.
通过多重衰减全反射和红外吸收光谱测量血糖。
DOI：
10.1109/10.55636
发表时间：
1990
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Mendelson,Y;Clermont,AC;Peura,RA;Lin,BC
通讯作者：
Lin,BC