Microvascular dysfunction and kidney disease: Challenges and opportunities?
Microvascular dysfunction and kidney disease: Challenges and opportunities?
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DOI：
10.1111/micc.12661
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Mohandas R
中科院分区：
文献类型：
--
作者：
Krishnan S;Suarez-Martinez AD;Bagher P;Gonzalez A;Liu R;Murfee WL;Mohandas R
肾脏是高度血管丰富的器官，尽管它们的体积相对较小，但它获得了心输出量的20%。肾脏微循环高度复杂、组织精细的结构是通过局部调节肾血流和肾小球内压来实现肾功能和肾小球滤过率所必需的。不足为奇的是，微血管内血流的失调(血管反应性异常)、由血管-肾脏串扰紊乱引起的纤维化或肾脏微血管的丧失(稀疏)与肾脏疾病有关。此外，肾脏疾病可导致心脏和大脑等远处器官的微循环功能障碍，其机制尚不清楚。本综述的目的是强调肾脏微血管在肾脏疾病中的作用。该综述将概述研究肾微血管的动力，肾脏疾病与微血管功能障碍之间的双向关系，导致微血管疾病的关键途径，如血管反应性，协调纤维化的细胞动力学，以及血管稀疏。最后，我们还将简要介绍针对肾微血管以改善肾功能的新疗法。
Kidneys are highly vascular organs that despite their relatively small size receive 20% of the cardiac output. The highly intricate, delicately organized structure of renal microcirculation is essential to enable renal function and glomerular filtration rate through the local modulation of renal blood flow and intraglomerular pressure. Not surprisingly, the dysregulation of blood flow within the microvessels (abnormal vasoreactivity), fibrosis driven by disordered vascular-renal cross talk, or the loss of renal microvasculature (rarefaction) is associated with kidney disease. In addition, kidney disease can cause microcirculatory dysfunction in distant organs such as the heart and brain, mediated by mechanisms that remain to be elucidated. The objective of this review is to highlight the role of renal microvasculature in kidney disease. The overview will outline the impetus to study renal microvasculature, the bidirectional relationship between kidney disease and microvascular dysfunction, the key pathways driving microvascular diseases such as vasoreactivity, the cell dynamics coordinating fibrosis, and vessel rarefaction. Finally, we will also briefly highlight new therapies targeting the renal microvasculature to improve renal function.
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发表时间：
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