Capillary rarefaction from the kidney point of view.
Capillary rarefaction from the kidney point of view.
复制标题
DOI：
10.1093/ckj/sfx133
复制
发表时间：
2018-06
影响因子：
4.6
通讯作者：
Kanbay M
中科院分区：
文献类型：
--
作者：
Afsar B;Afsar RE;Dagel T;Kaya E;Erus S;Ortiz A;Covic A;Kanbay M
毛细血管稀疏被广义地定义为血管密度的降低。认为肾脏中的毛细血管稀疏促进缺氧、损害血流动力学反应并易导致慢性肾病（CKD）进展和高血压发展。已提出多种机制在毛细血管稀疏的发展中起作用，包括炎症、改变的内皮-肾小管上皮细胞串扰、血管生成生长因子的相对缺乏、周细胞损失、转化生长因子-β1和血小板反应蛋白-1的活性增加、维生素D缺乏、与淋巴管新生血管形成和INK 4a/ARF（CDKN 2A）的联系。在这篇综述中，我们总结了在临床上无创监测毛细血管稀疏的工具，毛细血管稀疏对CKD和高血压的贡献，毛细血管稀疏的已知机制，以及潜在的未来策略，以减轻毛细血管稀疏，减少其负面影响。有待更详细探索的治疗策略包括优化抗高血压治疗、维生素D受体激活剂、沉默调节蛋白1激活剂、缺氧诱导因子脯氨酰羟化酶抑制剂和干细胞治疗。
Capillary rarefaction is broadly defined as a reduction in vascular density. Capillary rarefaction in the kidneys is thought to promote hypoxia, impair hemodynamic responses and predispose to chronic kidney disease (CKD) progression and hypertension development. Various mechanisms have been suggested to play a role in the development of capillary rarefaction, including inflammation, an altered endothelial-tubular epithelial cell crosstalk, a relative deficiency in angiogenic growth factors, loss of pericytes, increased activity of Transforming growth factor -β1 and thrombospondin-1, vitamin D deficiency, a link to lymphatic neoangiogenesis and INK4a/ARF (Cylin-dependent kinase inhibitor 2a; CDKN2A). In this review, we summarize the tools available to monitor capillary rarefaction noninvasively in the clinic, the contribution of capillary rarefaction to CKD and hypertension, the known mechanisms of capillary rarefaction, and potential future strategies to attenuate capillary rarefaction and reduce its negative impact. Therapeutic strategies to be explored in more detail include optimization of antihypertensive therapy, vitamin D receptor activators, sirtuin 1 activators, Hypoxia inducible factor prolyl hydroxylase inhibitors and stem cell therapy.
登录
查看更多内容
影响因子：
20.3
作者：
Franco, Marcela;Roswall, Pernilla;Pietras, Kristian
通讯作者：
Pietras, Kristian
影响因子：
6.1
作者：
Gatti, Stefano;Bruno, Stefania;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
--
作者：
CHEN, IIH;PREWITT, RL;DOWELL, RF
通讯作者：
DOWELL, RF
影响因子：
3.2
作者：
Debbabi, H;Uzan, L;Tibiriçà, E
通讯作者：
Tibiriçà, E
影响因子：
2.5
作者：
de Bragança AC;Volpini RA;Mehrotra P;Andrade L;Basile DP
通讯作者：
Basile DP