The human genome retains relics of its prokaryotic ancestry: human genes of archaebacterial and eubacterial origin exhibit remarkable differences.
The human genome retains relics of its prokaryotic ancestry: human genes of archaebacterial and eubacterial origin exhibit remarkable differences.
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DOI：
10.1093/gbe/evr073
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发表时间：
2011
影响因子：
3.3
通讯作者：
McInerney JO
中科院分区：
文献类型：
--
作者：
Alvarez-Ponce D;McInerney JO
真核生物通常被认为起源于古细菌和真细菌的融合事件。作为这一事件的结果，同时期的真核生物基因组是遗传自两个内共生伙伴的基因的嵌合体。这两种共存的基因库在酵母中有许多不同的方式。在这里，我们结合基因组和功能数据，以确定是否以及如何从两个原核祖先遗传的人类基因仍然是可区分的。我们发现，尽管数量较少，但源自古细菌的人类基因在组织中表达程度更高，表达范围更广，更有可能具有致死性小鼠同源基因，倾向于参与信息处理，更有选择性地受到约束，在蛋白质-蛋白质相互作用网络中编码更短、更中心的蛋白质，而不是像真细菌一样的基因。此外，与内共生理论一致，我们表明蛋白质倾向于与相同祖先基因编码的蛋白质相互作用。从人类健康的角度来看，最有趣的是，古细菌基因不太可能与遗传性人类疾病有关。综上所述，这些结果表明，在真核发生20多亿年之后，人类基因组至少保留了两个不同的基因群落。
Eukaryotes are generally thought to stem from a fusion event involving an archaebacterium and a eubacterium. As a result of this event, contemporaneous eukaryotic genomes are chimeras of genes inherited from both endosymbiotic partners. These two coexisting gene repertoires have been shown to differ in a number of ways in yeast. Here we combine genomic and functional data in order to determine if and how human genes that have been inherited from both prokaryotic ancestors remain distinguishable. We show that, despite being fewer in number, human genes of archaebacterial origin are more highly and broadly expressed across tissues, are more likely to have lethal mouse orthologs, tend to be involved in informational processes, are more selectively constrained, and encode shorter and more central proteins in the protein–protein interaction network than eubacterium-like genes. Furthermore, consistent with endosymbiotic theory, we show that proteins tend to interact with those encoded by genes of the same ancestry. Most interestingly from a human health perspective, archaebacterial genes are less likely to be involved in heritable human disease. Taken together, these results show that more than 2 billion years after eukaryogenesis, the human genome retains at least two somewhat distinct communities of genes.
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影响因子：
3.4
作者：
Bloom JD;Adami C
通讯作者：
Adami C
DOI：
10.1073/pnas.1000265107
发表时间：
2010-10-05
影响因子：
11.1
作者：
Cotton, James A.;McInerney, James O.
通讯作者：
McInerney, James O.
影响因子：
10.7
作者：
Pisani, Davide;Cotton, James A.;McInerney, James O.
通讯作者：
McInerney, James O.
影响因子：
10.7
作者：
Esser, C;Ahmadinejad, N;Martin, W
通讯作者：
Martin, W
影响因子：
14.9
作者：
Amberger J;Bocchini CA;Scott AF;Hamosh A
通讯作者：
Hamosh A