Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.
Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.
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DOI：
10.1002/stem.1003
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发表时间：
2012-03
期刊：
影响因子：
5.2
通讯作者：
Krause, Diane S.
中科院分区：
文献类型：
--
作者：
Kassmer, Susannah H.;Bruscia, Emanuela M.;Zhang, Ping-Xia;Krause, Diane S.
以往的研究表明，骨髓（BM）来源的细胞分化为多种组织的非造血细胞。迄今为止，仍不清楚哪种BM细胞群主要负责这种植入。为了检验骨髓中非造血干细胞是骨髓源性肺上皮细胞的主要来源这一假设，将野生型造血或非造血骨髓细胞移植到经辐照的表面活性蛋白C（SPC）缺失小鼠中。供体来源的SPC阳性2型肺细胞主要在接受纯化非造血细胞的小鼠的肺部中检测到，而在接受纯化造血干细胞和祖细胞的小鼠中则不存在。我们的结论是，骨髓的非造血部分中所含的细胞是骨髓来源的肺上皮细胞的主要来源。这些非造血细胞可能代表了存在于成人骨髓中的原始干细胞群。
Previous studies have demonstrated that bone marrow (BM)-derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow-derived lung epithelial cells, either wild-type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant-protein-C (SPC)-null mice. Donor-derived, SPC-positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow-derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM.
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影响因子：
2.6
作者：
Kassmer, Susannah H.;Krause, Diane S.
通讯作者：
Krause, Diane S.
影响因子：
82.9
作者：
Willenbring, H;Bailey, AS;Grompe, M
通讯作者：
Grompe, M
DOI：
10.1073/pnas.101500298
发表时间：
2001-05-22
影响因子：
11.1
作者：
Glasser, SW;Burhans, MS;Whitsett, JA
通讯作者：
Whitsett, JA
影响因子：
2.6
作者：
Aliotta, JM;Keaney, P;Quesenberry, PJ
通讯作者：
Quesenberry, PJ
影响因子：
4.8
作者：
Herzog, Erica L.;Van Arnam, John;Krause, Diane S.
通讯作者：
Krause, Diane S.