The role of CCN2 in cartilage and bone development.
The role of CCN2 in cartilage and bone development.
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DOI：
10.1007/s12079-011-0123-5
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发表时间：
2011-08
影响因子：
4.1
通讯作者：
Takigawa, Masaharu
中科院分区：
文献类型：
--
作者：
Kubota, Satoshi;Takigawa, Masaharu
CCN2是基质细胞蛋白CCN家族的经典成员，是通过新颖的分子作用协调软骨发育的关键分子。在脊椎动物的发育过程中，所有软骨的形成主要是一个间充质凝聚的过程，而CCN2的诱导促进了这一过程。之后，软骨发育成不同命运和任务的亚型，CCN2根据相应的微环境发挥相应的作用。CCN2在软骨和骨中的历史始于其在长骨生长软骨中的重新发现，它通过软骨内成骨过程决定骨骼的大小。CCN2不仅促进生长软骨的生理发育过程，也促进其他类型软骨的生理发育过程，如梅克尔软骨（Meckel’s软骨）代表无自钙化的暂时性软骨，关节软骨（关节软骨）代表具有物理刚度的透明软骨，耳软骨（耳软骨）代表弹性软骨。与其在膜内骨化中的重要作用一起，CCN2被认为是骨骼形成的导体。在软骨发育过程中，CCN2基因在转录和转录后水平上受到动态调控，以产生特定阶段的CCN2蛋白。在研究软骨细胞中这些调节系统的过程中，发现了已知生物分子的新功能方面。由于CCN2促进了这些组织的整体再生和生成（=发育），它在针对软骨细胞和成骨细胞的再生治疗中的应用已经得到了体内实验证据的支持。
CCN2, a classical member of the CCN family of matricellular proteins, is a key molecule that conducts cartilage development in a harmonized manner through novel molecular actions. During vertebrate development, all cartilage is primarily formed by a process of mesenchymal condensation, while CCN2 is induced to promote this process. Afterwards, cartilage develops into several subtypes with different fates and missions, in which CCN2 plays its proper roles according to the corresponding microenvironments. The history of CCN2 in cartilage and bone began with its re-discovery in the growth cartilage in long bones, which determines the skeletal size through the process of endochondral ossification. CCN2 promotes physiological developmental processes not only in the growth cartilage but also in the other types of cartilages, i.e., Meckel’s cartilage representing temporary cartilage without autocalcification, articular cartilage representing hyaline cartilage with physical stiffness, and auricular cartilage representing elastic cartilage. Together with its significant role in intramembranous ossification, CCN2 is regarded as a conductor of skeletogenesis. During cartilage development, the CCN2 gene is dynamically regulated to yield stage-specific production of CCN2 proteins at both transcriptional and post-transcriptional levels. New functional aspects of known biomolecules have been uncovered during the course of investigating these regulatory systems in chondrocytes. Since CCN2 promotes integrated regeneration as well as generation (=development) of these tissues, its utility in regenerative therapy targeting chondrocytes and osteoblasts is indicated, as has already been supported by experimental evidence obtained in vivo.
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影响因子：
--
作者：
Erwin, W. Mark;Ashman, Keith;Inman, Robert D.
通讯作者：
Inman, Robert D.
DOI：
10.1016/s0006-291x(02)00700-3
发表时间：
2002-07-12
影响因子：
3.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
6.2
作者：
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通讯作者：
Takigawa, Masaharu