Cutaneous adverse effects of the available COVID-19 vaccines.
Cutaneous adverse effects of the available COVID-19 vaccines.
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DOI：
10.1016/j.clindermatol.2021.04.001
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发表时间：
2021-05
影响因子：
2.7
通讯作者：
Tsankov N
中科院分区：
文献类型：
--
作者：
Bogdanov G;Bogdanov I;Kazandjieva J;Tsankov N
疫苗接种在改善全球健康方面发挥了至关重要的作用。世界上一些最致命的疾病，如天花和牛瘟，已在疫苗的帮助下被根除，许多其他疾病也得到了控制。 2019 冠状病毒病 (COVID-19) 严重急性呼吸系统综合症冠状病毒 2 毒株的出现及其对全球健康的影响，使得开发有效且安全的疫苗对于这种新的致命疾病至关重要。迄今为止，全球使用的COVID-19疫苗主要有三种类型：基于信使RNA的疫苗、腺病毒载体疫苗和灭活全病毒疫苗。其中一些已经通过了第3阶段的安全性和有效性试验，并广泛用于预防COVID-19感染。已有大量皮肤不良事件报道，其中大多数是轻度或中度注射部位反应。一些罕见的迟发性炎症反应（例如“新冠手臂”）也有报道，这对其病理生理学和临床重要性提出了疑问。一些罕见的严重不良事件，例如疫苗引起的血栓前免疫性血小板减少症和过敏反应，引起了人们对一些广泛传播的疫苗安全性的极大关注。需要收集更多数据并进行进一步、更详细的分析。这种严重不良反应的总体风险仍然极低，现有疫苗在对抗 COVID-19 广泛威胁方面的益处继续超过其副作用的风险。
Vaccination has played a crucial role in the improvement of global health. Some of the world’s deadliest diseases, like smallpox and rinderpest, have been eradicated with the help of vaccines, and many others have been restrained. The appearance of the strain of coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome coronavirus 2 and its impact on global health have made the development of effective and safe vaccines crucial for this new lethal disease. So far, there are three main types of COVID-19 vaccines in use around the world: messenger RNA–based vaccines, adenoviral vector vaccines, and inactivated whole-virus vaccines. Some of them have passed through phase 3 of safety and efficacy trials and are widely used for prophylaxis of COVID-19 infection. A plethora of cutaneous adverse events have been reported, most of them mild or moderate injection-site reactions. Some rare delayed inflammatory reactions such as “COVID arm” have also been reported, posing questions on their pathophysiology and clinical importance. Some rare serious adverse events, such as vaccine-induced prothrombotic immune thrombocytopenia and anaphylaxis, have been described raising great concerns on the safety of some widely spread vaccines. More data need to be collected with further and more detailed analysis. The overall risk of such severe adverse reactions remains extremely low, and the benefits of the existing vaccines in combating the widespread threat of COVID-19 continue to outweigh the risk of their side effects.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
7.8
作者：
Kounis NG;Koniari I;de Gregorio C;Velissaris D;Petalas K;Brinia A;Assimakopoulos SF;Gogos C;Kouni SN;Kounis GN;Calogiuri G;Hung MY
通讯作者：
Hung MY
影响因子：
5.9
作者：
Coors, EA;Seybold, H;Mahler, V
通讯作者：
Mahler, V
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1111/j.1468-3083.2007.02354.x
发表时间：
2008-02-01
影响因子：
9.2
作者：
Alijotas-Reig, J.;Garda-Gimenez, V.
通讯作者：
Garda-Gimenez, V.