CD28 costimulation is required for the expression of T-cell-dependent cell-mediated immunity against blood-stage Plasmodium chabaudi malaria parasites.
CD28 costimulation is required for the expression of T-cell-dependent cell-mediated immunity against blood-stage Plasmodium chabaudi malaria parasites.
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CD28 共刺激对于 T 细胞依赖性细胞介导的针对血液阶段恰鲍迪疟原虫疟原虫的免疫的表达是必需的。
DOI：
10.1128/iai.72.10.5768-5774.2004
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发表时间：
2004
影响因子：
3.1
通讯作者：
Weidanz,WilliamP
中科院分区：
文献类型：
--
作者：
Rummel,Thomas;Batchelder,Joan;Flaherty,Patrick;LaFleur,GayeLyn;Nanavati,Payal;Burns,JamesM;Weidanz,WilliamP
Mice suppress the parasitemia of acute blood-stagePlasmodium chabaudimalaria by an antibody- or T-cell-dependent cell-mediated mechanism of immunity (AMI and CMI, respectively) or by both mechanisms. To determine whether CD28 costimulation is required for expression of these polar immune responses, we first compared the time courses ofP. chabaudimalaria in CD28-deficient (CD28−/−) and CD28-intact (CD28+/+) mice. Acute infections in both knockout (KO) and control mice followed similar time courses, with the period of descending parasitemia being prolonged ∼2 weeks in KO mice followed by intermittent low-grade chronic parasitemia. Infected CD28−/−mice produced primarily the immunoglobulin M antibody, which upon passive transfer provided partial protection againstP. chabaudichallenge, suggesting that the elimination of blood-stage parasites by CD28−/−mice was achieved by AMI. To determine whether CD28−/−costimulation is required for the expression of CMI against the parasite, we compared the time courses of parasitemia in B-cell-deficient double-KO (JH−/−× CD28−/−) mice and control (JH−/−× CD28+/+) mice. Whereas control mice suppressed parasitemia to subpatent levels within ∼2 weeks postinoculation, double-KO mice developed high levels of parasitemia of long-lasting duration. Although not required for the suppression of acuteP. chabaudiparasitemia by AMI, CD28 costimulation is essential for the elimination of blood-stage parasites by CMI.
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297 家中过敏原水平：急性哮喘发作的危险因素
DOI：
--
发表时间：
1988
期刊：
影响因子：
--
作者：
S. Pollart;Chapman;T. Platts‐Mills
通讯作者：
T. Platts‐Mills
HIV免疫学和新疗法。
DOI：
10.1002/ppul.70052
发表时间：
2004
期刊：
Pediatric pulmonology. Supplement
影响因子：
--
作者：
Kolls,JayK
通讯作者：
Kolls,JayK
特应性儿童中猫过敏与狗过敏的频率和严重程度。
DOI：
10.1016/0091-6749(83)90522-5
发表时间：
1983
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
A. Murray;Alexander C. Ferguson;B. Morrison
通讯作者：
B. Morrison
使用猫和狗皮屑提取物进行免疫疗法。
影响因子：
14.2
作者：
H. Løwenstein;V. Graff‐Lonnevig;G. Hedlin;H. Heilborn;G. Lilja;K. Norrlind;K. Pegelow;B. Sundin
通讯作者：
B. Sundin
过敏人群中针对猫过敏原的 IgE 抗体。
影响因子：
14.2
作者：
J. Ohman;F. C. Lowell
通讯作者：
F. C. Lowell