Silencing of germline-expressed genes by DNA elimination in somatic cells.
Silencing of germline-expressed genes by DNA elimination in somatic cells.
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DOI：
10.1016/j.devcel.2012.09.020
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发表时间：
2012-11-13
影响因子：
11.8
通讯作者：
Davis RE
中科院分区：
文献类型：
--
作者：
Wang J;Mitreva M;Berriman M;Thorne A;Magrini V;Koutsovoulos G;Kumar S;Blaxter ML;Davis RE
Chromatin diminution is the programmed elimination of specific DNA sequences during development. It occurs in diverse species, but the function(s) of diminution and the specificity of sequence loss remain largely unknown. Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and leads to the loss of germline genome sequences and the formation of a distinct genome in somatic cells. We found that ~43 Mb (~13%) of genome sequence is eliminated in A. suum somatic cells, including ~12.7 Mb of unique sequence. The eliminated sequences and location of the DNA breaks are the same in all somatic lineages from a single individual, and between different individuals. At least 685 genes are eliminated. These genes are preferentially expressed in the germline and during early embryogenesis. We propose that diminution is a mechanism of germline gene regulation that specifically removes a large number of genes involved in gametogenesis and early embryogenesis.
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影响因子：
64.5
作者：
Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
通讯作者：
Miska EA
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
1.5
作者：
Bachmann-Waldmann, C;Jentsch, S;Müller, F
通讯作者：
Müller, F
DOI：
10.1073/pnas.76.3.1333
发表时间：
1979-01-01
影响因子：
11.1
作者：
EMMONS, SW;KLASS, MR;HIRSH, D
通讯作者：
HIRSH, D
影响因子：
64.8
作者：
Buckley, Bethany A.;Burkhart, Kirk B.;Gu, Sam Guoping;Spracklin, George;Kershner, Aaron;Fritz, Heidi;Kimble, Judith;Fire, Andrew;Kennedy, Scott
通讯作者：
Kennedy, Scott