Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment.
Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment.
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建立胎盘疟疾对婴儿神经发育影响的概念框架。
DOI：
10.1016/j.ijid.2019.04.019
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Bora,Samudragupta
中科院分区：
文献类型：
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作者：
Lawford,HarrietLS;Lee,AnneCc;Kumar,Sailesh;Liley,HelenG;Bora,Samudragupta
提出了一个新的概念框架来描述胎盘疟疾和不良婴儿神经发育结果之间的关系。这一概念框架包括三个不同的阶段：(1)导致胎盘疟疾发展的孕产妇和环境风险因素；(2)与胎盘疟疾感染相关的胎盘病理及炎症；(3)胎盘疟疾的产后影响。这些风险因素在三个阶段对婴儿神经发育的直接、间接和双向影响进行了严格的检查。这些因素最终导致婴儿表型，不仅会导致不良的出生结果，还会增加神经、认知和行为缺陷的风险，这些风险可能会影响这一高危人群的生活质量。在这一概念框架中确定了多种风险因素；尽管如此，根据目前的证据，一个关键的知识差距是不确定哪些是最重要的，以及它们如何确切地相互作用。
A novel conceptual framework to describe the relationship between placental malaria and adverse infant neurodevelopmental outcomes is proposed. This conceptual framework includes three distinct stages: (1) maternal and environmental risk factors for the development of placental malaria; (2) placental pathology and inflammation associated with placental malaria infection; and (3) postnatal impacts of placental malaria. The direct, indirect, and bidirectional effects of these risk factors on infant neurodevelopment across the three stages were critically examined. These factors ultimately culminate in an infant phenotype that not only leads to adverse birth outcomes, but also to increased risks of neurological, cognitive, and behavioural deficits that may impact the quality of life in this high-risk population. Multiple risk factors were identified in this conceptual framework; nonetheless, based on current evidence, a key knowledge gap is the uncertainty regarding which are the most important and how exactly they interact.
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T.Uchida；R.Fukuda 等：肝病学。
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