Role of optical coherence tomography angiography in the characterization of vascular network patterns of ocular surface squamous neoplasia.
Role of optical coherence tomography angiography in the characterization of vascular network patterns of ocular surface squamous neoplasia.
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DOI：
10.1016/j.jtos.2020.03.009
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发表时间：
2020-10
期刊：
影响因子：
6.4
通讯作者：
Wang, Jianhua
中科院分区：
文献类型：
--
作者：
Liu, Zhiping;Karp, Carol L.;Galor, Anat;Al Bayyat, Ghada J.;Jiang, Hong;Wang, Jianhua
关键词：
To visualize and quantify vascular networks in individuals with ocular surface squamous neoplasia (OSSN) through optical coherence tomography angiography (OCTA). Cross-sectional study of OSSN patients. Vascular networks were measured by OCTA in the epithelium and sub-epithelial space in the tumors, adjacent tissue, and in the contralateral eye. Vessel area density (VAD, percent of blood vessels within 2.14 mm2), was calculated for each location. Total tumor density (TTD, percent of blood vessels within the entire tumor) was calculated. VAD was assessed separately for corneal and conjunctival locations and compared. Fifteen patients with OSSN were included. The mean age was 61 ± 12 years and the majority were male (80%). The mean tumor area, volume, depth, VAD, and TTD were 28.6 ± 8.1 mm2 (range, 14.1–39.0), 9.1 ± 4.2 mm3 (range, 3.4–18.8), 317 ± 107 μm (range, 177–570), and 32.2% ± 11.7% (range, 18.3–58.8), respectively. The VAD was highest under the conjunctival component of tumor (42.6% ± 9.6%) followed by within the conjunctival tumor (32.8% ± 8.3%). These densities were higher than the VADs measured in all other tissues (all P < 0.01). The VAD within conjunctival component of tumor was significantly higher than those with corneal component (33.5% ± 9.6% vs. 26.8% ± 6.1%, p = 0.046). The VAD under conjunctival tumor was also significantly higher than under corneal component (46.4% ± 8.6% vs. 35.2% ± 5.6%, p = 0.001). OCTA imaging allowed for visualization and quantification of vessel structure and density within, under, and surrounding OSSN.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
DOI：
10.1016/j.jtos.2016.12.002
发表时间：
2017-04
期刊：
The ocular surface
影响因子：
--
作者：
Chen W;Batawi HI;Alava JR;Galor A;Yuan J;Sarantopoulos CD;McClellan AL;Feuer WJ;Levitt RC;Wang J
通讯作者：
Wang J
影响因子：
4.2
作者：
Akagi T;Uji A;Huang AS;Weinreb RN;Yamada T;Miyata M;Kameda T;Ikeda HO;Tsujikawa A
通讯作者：
Tsujikawa A
影响因子：
3.3
作者：
Cicinelli MV;Marchese A;Bandello F;Modorati G
通讯作者：
Modorati G
影响因子：
2
作者：
Brunner, Matthias;Steger, Bernhard;Kaye, Stephen B.
通讯作者：
Kaye, Stephen B.