Conjunctival and Intrascleral Vasculatures Assessed Using Anterior Segment Optical Coherence Tomography Angiography in Normal Eyes.
Conjunctival and Intrascleral Vasculatures Assessed Using Anterior Segment Optical Coherence Tomography Angiography in Normal Eyes.
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DOI：
10.1016/j.ajo.2018.08.009
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发表时间：
2018-12
影响因子：
4.2
通讯作者：
Tsujikawa A
中科院分区：
文献类型：
--
作者：
Akagi T;Uji A;Huang AS;Weinreb RN;Yamada T;Miyata M;Kameda T;Ikeda HO;Tsujikawa A
使用前段（AS）光学相干断层扫描血管造影（OCTA）研究正常眼的结膜和巩膜内脉管系统。横断面研究。使用扫频 OCT 系统在 10 名健康受试者的 10 只眼睛中获取角膜缘的 AS-OCTA 图像。比较浅层（从结膜上皮到 200 μm 深度）和深层（从 200 μm 到 1000 μm 深度）层之间具有正面最大投影的 AS-OCTA 血流模式。还将 OCTA 图像与荧光素巩膜血管造影和吲哚菁绿水性血管造影图像进行比较。比较不同位置之间的定量参数（血管密度、血管长度密度、血管直径指数和分形维数）。 OCTA 血管模式在浅层和深层之间有所不同。浅层血流信号显示来自角膜缘的离心模式，而深层血流信号显示分段模式。具有完整信号的 OCTA en 面部图像与巩膜血管造影图像具有相似的外观，而深层的图像与水性血管造影图像具有相似的外观。在浅层中，只有血管直径指数在不同位置之间存在显着差异（P = 0.003）。在深层中，所有四个参数在不同位置之间差异显着（P < 0.001 至 P = 0.003）。 OCTA 是评估结膜和巩膜内脉管系统的有前途的工具。它还可能有助于了解与血管和眼表疾病相关的眼表血流以及房水流出。
To investigate conjunctival and intrascleral vasculatures using anterior-segment (AS) optical coherence tomography angiography (OCTA) in normal eyes. Cross-sectional study. AS-OCTA images of the corneal limbus were acquired circumferentially using a swept-source OCT system in 10 eyes of 10 healthy subjects. AS-OCTA flow patterns with en face maximum projection were compared between the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The OCTA images were also compared with fluorescein scleral angiography and indocyanine green aqueous angiography images. Quantitative parameters (vessel density, vessel length density, vessel diameter index, and fractal dimension) were compared among different locations. The OCTA vessel patterns differed between the superficial and deep layers. The superficial-layer flow signals showed centrifugal patterns from the limbus, whereas the deep-layer flow signals showed segmental patterns. The OCTA en face images with whole signals had a similar appearance to the scleral angiography images, whereas those in the deep layer showed a similar appearance to the aqueous angiography images. In the superficial layer, only the vessel diameter index was significantly different among the locations (P = 0.003). In the deep layer, all four parameters differed significantly among the locations (P < 0.001 to P = 0.003). OCTA is a promising tool for evaluating conjunctival and intrascleral vasculatures. It may also help in understanding ocular surface blood flow relevant to vascular and ocular surface diseases, as well as aqueous humor outflow.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
DOI：
10.1016/j.jtos.2016.12.002
发表时间：
2017-04
期刊：
The ocular surface
影响因子：
--
作者：
Chen W;Batawi HI;Alava JR;Galor A;Yuan J;Sarantopoulos CD;McClellan AL;Feuer WJ;Levitt RC;Wang J
通讯作者：
Wang J
影响因子：
13.7
作者：
Huang, Alex S.;Camp, Andrew;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.
影响因子：
4.4
作者：
Francis, Andrew W.;Kagemann, Larry;Schuman, Joel S.
通讯作者：
Schuman, Joel S.