The effects of theophylline on airway inflammation.
The effects of theophylline on airway inflammation.
复制标题
茶碱对气道炎症的影响。
作者:
R. Pauwels
One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation. This hypothesis is based on in vitro and in vivo studies demonstrating that theophylline at therapeutic concentrations has an inhibitory activity on airway inflammation induced by allergic and nonallergic stimuli. Indirect evidence suggests that airway inflammation is an important determinant in the long-term outcome of chronic obstructive airway disease. The effect of theophylline on the long-term evolution of chronic obstructive lung disease remains to be proven.
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DOI:
10.1164/arrd.1983.127.6.686
发表时间:
1983
期刊:
The American review of respiratory disease
影响因子:
--
作者:
Holtzman,MJ;Fabbri,LM;O'Byrne,PM;Gold,BD;Aizawa,H;Walters,EH;Alpert,SE;Nadel,JA
通讯作者:
Nadel,JA
DOI:
10.1016/0091-6749(86)90086-2
发表时间:
1986
期刊:
The Journal of allergy and clinical immunology
影响因子:
--
作者:
Nielson,CP;Crowley,JJ;Cusack,BJ;Vestal,RE
通讯作者:
Vestal,RE
DOI:
10.1073/pnas.81.19.6192
发表时间:
1984-01-01
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子:
--
作者:
MARQUARDT, DL;GRUBER, HE;WASSERMAN, SI
通讯作者:
WASSERMAN, SI
DOI:
10.1152/jappl.1983.54.6.1463
发表时间:
1983
期刊:
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子:
--
作者:
Hutchison,AA;HinsonJr,JM;Brigham,KL;Snapper,JR
通讯作者:
Snapper,JR
DOI:
10.1164/arrd.1984.130.2.214
发表时间:
1984
期刊:
The American review of respiratory disease
影响因子:
--
作者:
O'Byrne,PM;Walters,EH;Gold,BD;Aizawa,HA;Fabbri,LM;Alpert,SE;Nadel,JA;Holtzman,MJ
通讯作者:
Holtzman,MJ