Bioavailability of calcium and phosphorus in human milk fortifiers and formula for very low birth weight infants.
Bioavailability of calcium and phosphorus in human milk fortifiers and formula for very low birth weight infants.
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母乳强化剂和极低出生体重婴儿配方奶粉中钙和磷的生物利用度。
DOI：
10.1016/s0022-3476(88)80541-9
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
C. Garza
中科院分区：
文献类型：
--
作者：
R. Schanler;S. Abrams;C. Garza
对22名极低出生体重儿的生长、96小时营养平衡（氮、脂肪、钙（Ca）、磷（P）和镁）、代谢能和矿物质状态的血清生化标志物（Ca和P浓度和碱性磷酸酶活性）进行了测定，以研究来自专门配方奶粉和人乳强化剂的矿物质的生物利用度。FORM组（“早产儿”SMA）和CMF组（1：1 wt/wt，人乳和Similac Natural Care或Similac Special Care）之间的Ca和P摄入量相似。氮、能量、脂肪和镁的摄入量在各组之间存在差异。与FORM组相比，CMF组的粪便损失量显著增加，钙和磷的吸收和存留量显著降低。然而，两组的Ca和P保留值均低于宫内估计值的25%。钙、磷和镁的保留率与其各自的摄入量无关。CMF组在平衡研究期间和整个研究期间的体重增加显著较少。CMF组的钙潴留与体重增加或氮潴留的比值较低，这表明钙潴留较低与这些婴儿生长速度较慢有关，而不是与粪便中钙的大量丢失有关。虽然这组中钙和磷的粪便损失更大的原因尚不清楚，但数据表明矿物质来源的不溶性。我们的研究结果表明，完全依赖于绝对矿物质浓度的牛奶选择极低出生体重儿可能是不现实的，钙和磷的生物利用度从特定的矿物质来源应进行评估。
Growth, 96-hour balance of nutrients (nitrogen, fat, calcium (Ca), phosphorus (P), and magnesium), metabolizable energy, and serum biochemical markers of mineral status (Ca and P concentrations and alkaline phosphatase activity) were measured in 22 very low birth weight infants to investigate the bioavailability of minerals from specialized formula and from human milk fortifiers. The intakes of Ca and P were similar between group FORM (“Preemie” SMA) and group CMF (1:1 wt/wt, human-milk and Similac Natural Care or Similac Special Care). The intakes of nitrogen, energy, fat, and magnesium differed between groups. Group CMF had significantly greater fecal losses and significantly lower absorption and retention of Ca and P in comparison with those of group FORM. Retention of Ca and P in both groups, however, was >25% below intrauterine estimates of accretion. Retention rates of Ca, P, and magnesium were not correlated with their respective intakes. Weight gain during the balance study and during the entire study interval was significantly less in group CMF. The ratio of Ca retention to either weight gained or nitrogen retained was lower in group CMF, which suggested that the low retention of Ca was related less to the slower rate of growth in these infants than to their greater fecal losses of Ca. Although the cause of the greater fecal losses of Ca and P in this group is unclear, the data suggest an insolubility of the mineral sources. Our results indicate that sole reliance on the absolute mineral concentrations of the milk selected for very low birth weight infants may be unrealistic; the bioavailability of Ca and P from particular mineral sources should be evaluated.
影响因子：
158.5
作者：
SHEIKH, MS;SANTAANA, CA;FORDTRAN, JS
通讯作者：
FORDTRAN, JS