Systemic immunity in cancer.
Systemic immunity in cancer.
复制标题
癌症的全身免疫。
DOI：
10.1038/s41568-021-00347-z
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Spitzer MH
中科院分区：
文献类型：
--
作者：
Hiam-Galvez KJ;Allen BM;Spitzer MH
免疫疗法已经彻底改变了癌症治疗，但在大多数临床环境中疗效仍然有限。癌症是一种全身性疾病，它会引起整个免疫系统的许多功能和组成变化。免疫力受到组织中不同细胞谱系相互作用的调节。因此，对肿瘤免疫学的更好理解必须评估肿瘤微环境（TME）之外的全身免疫景观。重要的是，需要外周免疫系统来驱动有效的天然和治疗诱导的抗肿瘤免疫应答。事实上，新出现的证据表明，免疫疗法驱动新的免疫反应，而不是重新激活先前存在的免疫反应。然而，患有肿瘤的个体的新免疫应答甚至在TME之后也会受到损害。在此，我们的目的是全面概述目前的知识，全身免疫的癌症。对肿瘤免疫学和治疗的更好理解必须评估肿瘤微环境之外的全身免疫景观。这篇综述概述了外周免疫细胞重组对肿瘤生长和治疗的反应，它们对免疫治疗反应的贡献以及它们作为诊断或预测生物标志物的潜力。
Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most clinical settings. Cancer is a systemic disease that induces many functional and compositional changes to the immune system as a whole. Immunity is regulated by interactions of diverse cell lineages across tissues. Therefore, an improved understanding of tumour immunology must assess the systemic immune landscape beyond the tumour microenvironment (TME). Importantly, the peripheral immune system is required to drive effective natural and therapeutically induced antitumour immune responses. In fact, emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. However, new immune responses in individuals burdened with tumours are compromised even beyond the TME. Herein, we aim to comprehensively outline the current knowledge of systemic immunity in cancer. An improved understanding of tumour immunology and therapy must assess the systemic immune landscape beyond the tumour microenvironment. This Review outlines peripheral immune cell reorganization in response to tumour growth and therapy, their contribution to immunotherapy responses and their potential as diagnostic or predictive biomarkers.
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影响因子：
10.9
作者：
Capone M;Giannarelli D;Mallardo D;Madonna G;Festino L;Grimaldi AM;Vanella V;Simeone E;Paone M;Palmieri G;Cavalcanti E;Caracò C;Ascierto PA
通讯作者：
Ascierto PA
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
24.8
作者：
Ahmadzadeh, Mojgan;Pasetto, Anna;Rosenberg, Steven A.
通讯作者：
Rosenberg, Steven A.
影响因子：
64.5
作者：
Binnewies, Mikhail;Mujal, Adriana M.;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.
DOI：
10.1073/pnas.1620433114
发表时间：
2017-01-31
影响因子：
11.1
作者：
Chamoto, Kenji;Chowdhury, Partha S.;Honjo, Tasuku
通讯作者：
Honjo, Tasuku