Spatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging.

Spatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging.
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DOI:
10.1016/j.ymeth.2014.10.025
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发表时间:
2015-02
期刊:
影响因子:
4.8
通讯作者:
Huang, Hao
Huang, Hao
中科院分区:
生物学3区
文献类型:
--
作者:
Ouyang, Austin;Jeon, Tina;Sunkin, Susan M.;Pletikos, Mihovil;Sedmak, Goran;Sestan, Nenad;Lein, Ed S.;Huang, Hao

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在人类大脑从胎儿期到成年期的发育过程中,白色束发生了巨大的变化。扩散张量成像(DTI)是一种广泛使用的磁共振成像(MRI)模式,它提供了对WM纤维动态变化的洞察,因为这些纤维可以无创地追踪和三维(3D)重建与DTI纤维束成像。DTI和常规T1加权MRI图像还提供了足够的皮质解剖细节,用于标测皮质感兴趣区域(ROI)。在本文中,我们描述了DTI技术的基本概念和方法,可用于追踪主要的WM束无创从胎儿的14 postconceptional周(pcw)到成人大脑。我们应用这些技术来获取DTI数据和跟踪,重建和可视化主要WM束在发展过程中。在将主要的WM纤维束分为五个独特的功能束组,即边缘系统,脑干,投射,连合和联合束,我们揭示了这些三维重建的WM束的发育中的人脑的形成和成熟。DTI提供的结构和连接成像数据提供了发育中的人脑转录图谱的解剖学基础。
During human brain development from fetal stage to adulthood, the white matter (WM) tracts undergo dramatic changes. Diffusion tensor imaging (DTI), a widely used magnetic resonance imaging (MRI) modality, offers insight into the dynamic changes of WM fibers as these fibers can be noninvasively traced and three-dimensionally (3D) reconstructed with DTI tractography. The DTI and conventional T1 weighted MRI images also provide sufficient cortical anatomical details for mapping the cortical regions of interests (ROIs). In this paper, we described basic concepts and methods of DTI techniques that can be used to trace major WM tracts noninvasively from fetal brain of 14 postconceptional weeks (pcw) to adult brain. We applied these techniques to acquire DTI data and trace, reconstruct and visualize major WM tracts during development. After categorizing major WM fiber bundles into five unique functional tract groups, namely limbic, brain stem, projection, commissural and association tracts, we revealed formation and maturation of these 3D reconstructed WM tracts of the developing human brain. The structural and connectional imaging data offered by DTI provides the anatomical backbone of transcriptional atlas of the developing human brain.
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