Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.
Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.
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DOI：
10.3389/fnins.2018.00214
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发表时间：
2018
影响因子：
4.3
通讯作者：
Maher P
中科院分区：
文献类型：
--
作者：
Lewerenz J;Ates G;Methner A;Conrad M;Maher P
虽然神经细胞死亡是许多神经系统疾病的标志，但这种死亡背后的过程仍然不清楚。然而，有一个普遍的共识，即神经元细胞死亡主要是通过调节过程进行的。大约30年前，在神经元细胞中描述了一种最终命名为氧化病的细胞死亡途径，涉及谷胱甘肽耗竭、活性氧产生、脂氧合酶激活和钙内流。最近，在肿瘤细胞中描述了一种涉及许多相同步骤的细胞死亡途径，由于对铁的依赖，称为铁凋亡。从那时起，在文献中有大量的讨论，关于这是两种不同的途径还是同一途径上的细胞类型和胰岛素依赖性变异。在这篇综述中，我们详细比较和对比了这两种途径之间的共性和区别，得出结论，参与铁凋亡和氧化调节的分子途径高度相似，如果不是相同的。因此，我们认为，氧化和铁凋亡应被视为同一个细胞死亡途径的两个名称。此外，我们描述了潜在的生理相关性的氧化/铁凋亡在多种神经系统疾病。
Although nerve cell death is the hallmark of many neurological diseases, the processes underlying this death are still poorly defined. However, there is a general consensus that neuronal cell death predominantly proceeds by regulated processes. Almost 30 years ago, a cell death pathway eventually named oxytosis was described in neuronal cells that involved glutathione depletion, reactive oxygen species production, lipoxygenase activation, and calcium influx. More recently, a cell death pathway that involved many of the same steps was described in tumor cells and termed ferroptosis due to a dependence on iron. Since then there has been a great deal of discussion in the literature about whether these are two distinct pathways or cell type- and insult-dependent variations on the same pathway. In this review, we compare and contrast in detail the commonalities and distinctions between the two pathways concluding that the molecular pathways involved in the regulation of ferroptosis and oxytosis are highly similar if not identical. Thus, we suggest that oxytosis and ferroptosis should be regarded as two names for the same cell death pathway. In addition, we describe the potential physiological relevance of oxytosis/ferroptosis in multiple neurological diseases.
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影响因子：
5.3
作者：
Calderone, A;Jover, T;Zukin, RS
通讯作者：
Zukin, RS
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
DOI：
10.1073/pnas.0606526103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Andrabi, Shaida A.;Kim, No Soo;Dawson, Ted M.
通讯作者：
Dawson, Ted M.
影响因子：
6.1
作者：
Buhmann, C;Arlt, S;Beisiegel, U
通讯作者：
Beisiegel, U
影响因子：
12.4
作者：
Cabon, L.;Galan-Malo, P.;Susin, S. A.
通讯作者：
Susin, S. A.