Nationwide survey of fertility preservation in patients with hematological malignancies in Japan

Nationwide survey of fertility preservation in patients with hematological malignancies in Japan
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日本全国血液系统恶性肿瘤患者生育力保存情况调查

DOI:
10.1007/s10147-020-01801-y
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发表时间:
2021
期刊:
Int J Clin Oncol.
影响因子:
--
通讯作者:
Osuga Y.
Osuga Y.
中科院分区:
--
文献类型:
--
作者:
Okamoto S;Fujii N;Yoshioka N;Harada M;Tanimoto M;Maeda Y;Suzuki N;Osuga Y.

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背景在世界范围内,对肿瘤生育问题的兴趣越来越大。2017年,日本临床肿瘤学会发布了癌症患者生育力保护(FP)的临床实践指南。我们进行了一项问卷调查,以探讨FP的做法,在血液科医生出版之前,本guidely.MethodsWe发送了427指定的癌症医院在日本的一份调查问卷,关于FP治疗的血液恶性肿瘤患者之间的2014年1月至12月。结果,其中,137个机构回答,81(19.0%)被纳入分析。共治疗了324名女性和441名男性患者,年龄< 40岁。接受造血细胞移植治疗的患者中知晓FP的患者比例高于未接受造血细胞移植治疗的患者。女性患者不太可能被告知FP比男性患者。共对27例女性患者进行了FP:20例卵母细胞冷冻保存,2例胚胎冷冻保存,3例卵巢组织冷冻保存,2例全身照射期间卵巢屏蔽。在115名男性patients.ConclusionsOur研究结果表明,在2014年,指南发布之前,生育力保存的现实。自指南发布以来,有必要进行进一步的研究,以调查生育力保存的改善情况。
BackgroundWorldwide, there has been a growing interest in oncofertility issues. In 2017, the Japanese Society of Clinical Oncology published clinical practice guidelines for fertility preservation (FP) in cancer patients. We conducted a questionnaire survey to explore the FP practices among hematologists before the publication of this guideline.MethodsWe sent 427 designated cancer hospitals in Japan a questionnaire about FP treatment for patients with hematological malignancies between January and December 2014.ResultsOf these, 137 institutions responded, and 81 (19.0%) were included in the analysis. A total of 324 female and 441 male patients, aged < 40 years, were treated. The percentage of patients informed about FP was higher in patients treated with hematopoietic cell transplant than those without. Female patients were less likely to be informed about FP than male patients. FP was performed in a total of 27 female patients: 20 oocyte cryopreservation, 2 embryo cryopreservation, 3 ovarian tissue cryopreservation, and 2 ovarian shielding during total body irradiation. Sperm cryopreservation was performed in 115 male patients.ConclusionsOur findings indicate the reality of fertility preservation in 2014, before the guideline were issued. Further studies are warranted to investigate the improvement in fertility preservation since the guidelines were issued.
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