Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats
Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats
复制标题
酒精抑制大鼠吗啡/可卡因奖赏记忆的获得和再巩固
DOI：
10.1007/s00213-019-05433-7
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Yanqin Li
中科院分区：
文献类型：
--
作者：
Mingzhu Chen;Pingping Chen;Shimin Zhu;Yanqin Li
基本原理和目标酒精是一种娱乐性物质，在世界上大多数地区都是社会普遍接受的法律的。过量饮酒会对大脑产生抑制作用，损害认知和记忆。在这项研究中，我们研究了酒精对吗啡和可卡因诱导的大鼠药物奖赏记忆的获得、巩固和再巩固的影响。和可卡因（10 mg/kg，i. p.）条件性位置偏好（CPP）是一种无偏的CPP范式。溶剂或酒精（0.25、0.75、1.5 g/kg，i. p.）在不同的时间点给药，包括每次CPP调节期前30分钟（采集）、每次CPP调节期后立即（巩固）、CPP再激活后立即（再暴露再巩固）或未重新激活药物配对环境（未再暴露再巩固）。条件反射得分记录之前或之后，每个条件反射会话或内存reactivation.ResultsAlcohol在剂量为1.5 g/kg，但不是0.25 g/kg或0.75 g/kg显着抑制收购和再巩固吗啡和可卡因相关的内存。与此相反，酒精没有影响巩固吗啡或可卡因诱导的CPP.ConclusionsThe结果表明，预暴露酒精剂量依赖性衰减吗啡或可卡因诱导的位置偏爱，并阻止药物恢复大鼠通过破坏记忆的再巩固，这可能是由酒精对多巴胺能和多巴胺能神经传递的抑制作用来解释。
Rationale and objectiveAlcohol is a recreational substance that is generally socially acceptable and legal in most areas worldwide. An alcohol overdose will produce an inhibitory effect on the brain and impair cognition and memory. In this study, we examined the effect of alcohol on the acquisition, consolidation, and reconsolidation of drug reward memory induced by morphine and cocaine in rats.MethodsRats were trained to acquire morphine sulfate (10 mg/kg, s.c.) and cocaine (10 mg/kg, i.p.) conditioned place preference (CPP) via an unbiased CPP paradigm. Vehicle or alcohol (0.25, 0.75, 1.5 g/kg, i.p.) was administered at various time-points, including 30 min before each CPP conditioning session (acquisition), immediately after each CPP conditioning session (consolidation), immediately after the reactivation of CPP (reconsolidation with re-exposure), or without reactivation to the drug-paired context (reconsolidation without re-exposure). Conditioning scores were recorded before or after each conditioning session or memory reactivation.ResultsAlcohol at a dose of 1.5 g/kg but not 0.25 g/kg or 0.75 g/kg significantly inhibited the acquisition and reconsolidation of morphine- and cocaine-associated memory. In contrast, alcohol had no effect on the consolidation of morphine- or cocaine-induced CPP.ConclusionsThe results suggested that pre-exposure alcohol dose-dependently attenuated morphine- or cocaine-induced place preference and prevented drug reinstatement in rats by disrupting memory reconsolidation, which may be explained by the inhibitory effect of alcohol on dopaminergic and glutamatergic neurotransmission.
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DOI：
10.1523/jneurosci.5884-10.2011
发表时间：
2011-04-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Li YQ;Xue YX;He YY;Li FQ;Xue LF;Xu CM;Sacktor TC;Shaham Y;Lu L
通讯作者：
Lu L
影响因子：
16.2
作者：
Miller, CA;Marshall, JF
通讯作者：
Marshall, JF
DOI：
10.1073/pnas.1017856108
发表时间：
2011-04-19
影响因子：
11.1
作者：
Hicklin, Tianna R.;Wu, Peter H.;Browning, Michael D.
通讯作者：
Browning, Michael D.
影响因子：
5.3
作者：
Schindler, Abigail G.;Soden, Marta E.;Clark, Jeremy J.
通讯作者：
Clark, Jeremy J.
影响因子：
3.4
作者：
DelPozo, E;Barrios, M;Baeyens, JM
通讯作者：
Baeyens, JM