Febrile Convulsions in 220 Children – Neurological Sequelae at 12 Years Follow-Up
Febrile Convulsions in 220 Children – Neurological Sequelae at 12 Years Follow-Up
复制标题
220 名儿童热性惊厥——12 年随访的神经系统后遗症
作者：
B. Macdonald;A. Johnson;Josemir W Sander;S. Shorvon
我们报告了一项对儿童发热性惊厥（fc）的12年随访研究。国家癫痫全科实践研究（NGPSE）是一项大型前瞻性社区队列研究，研究对象为1195名所有年龄的患者，从首次出现癫痫发作开始。在1984年至1987年间，有220名儿童首次出现热性惊厥。对儿童进行前瞻性随访，以确定随后的癫痫发作、神经问题和治疗情况。277例患者随访至少8.4年（中位11.2年）。在FC队列中，6%的儿童随后发展为癫痫，而人群风险约为1.4%。10%的人有神经系统后遗症。11%的儿童接受了预防FC复发的药物治疗，其中三分之一是针对简单的FC。使用时间相关的协变量Cox比例风险模型，fc的数量与癫痫风险增加相关（风险比2.48；95%置信限，CL 1.68, 3.65），最高可达4。复杂FC的发生与随后的癫痫之间没有统计学上的显著关联，但对其他研究的回顾量化了复杂首次FC后癫痫的优势比为3.4 （95% CL 2.1, 5.4）。癫痫虽不常见，但却是fc的重要后遗症。与继发癫痫相关的因素是FC的数量或复杂的首次FC。对这种情况的过度治疗仍在继续。
We report a 12-year follow-up study of children with febrile convulsions (FCs). The National General Practice Study of Epilepsy (NGPSE) is a large prospective community-based cohort study of 1,195 patients of all ages from first presentation with an identified seizure. Two hundred and twenty children with a first febrile convulsion were identified from the above study between 1984 and 1987. Children were prospectively followed up to ascertain subsequent seizures, neurological problems and treatment. Two hundred and seven patients were followed for a minimum of 8.4 years (median 11.2 years). In the FC cohort, 6% of the children developed subsequent epilepsy, which compares with a population risk of about 1.4%. Ten percent had neurological sequelae. Eleven percent of the children had received medication to prevent recurrence of FC, and in one third of these cases, this was for simple FCs. Using a time-dependent covariate Cox proportional hazards model, the number of FCs was associated with an increased risk of epilepsy (hazard ratio 2.48; 95% confidence limits, CL 1.68, 3.65) up to a limit of 4. A statistically significant association between occurrence of complex FC and subsequent epilepsy was not found, but a review of other studies quantified the odds ratio for epilepsy after a complex first FC as 3.4 (95% CL 2.1, 5.4). Epilepsy is a significant if infrequent sequel to FCs. Factors associated with subsequent epilepsy are the number of FCs or a complex first FC. Overtreatment of this condition continues.
影响因子：
158.5
作者：
FARWELL, JR;LEE, YJ;NELSON, KB
通讯作者：
NELSON, KB
影响因子：
158.5
作者：
ANNEGERS, JF;HAUSER, WA;KURLAND, LT
通讯作者：
KURLAND, LT
影响因子：
5
作者：
CASSANO, PA;KOEPSELL, TD;FARWELL, JR
通讯作者：
FARWELL, JR