Measurement of short-term 11C-thymidine activity in human head and neck tumours using positron emission tomography (PET).

Measurement of short-term 11C-thymidine activity in human head and neck tumours using positron emission tomography (PET).
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使用正电子发射断层扫描 (PET) 测量人类头颈部肿瘤的短期 11C-胸苷活性。

DOI:
10.3109/02841869209088303
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发表时间:
1992
期刊:
影响因子:
3.1
通讯作者:
Christian R. De Potter
Christian R. De Potter
中科院分区:
医学3区
文献类型:
--
作者:
Marc E. van Eijkeren;André De Schyver;Patrick Goethals;E. Poupeye;Karel Schelstraete;I. Lemahieu;Christian R. De Potter

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在13例头颈部肿瘤患者静脉注射11 C-胸苷标记的甲基位置后,肿瘤摄取进行了评估。该活性与其他示踪剂如C15 O、13 NH3和C15 O2进行了比较。在每一个单一的情况下,一个'积极的'肿瘤图像后,注射11 C-胸苷获得。时间-活性曲线显示,初始活性随后在前10-15分钟内迅速下降,此后出现明显的平台期。在正常唾液腺区域和心肌中发现了类似的摄取水平,而在肝和肾实质中发现了更高的活性。有人建议,血流和细胞代谢可以影响11 C-胸苷成像在这类人类肿瘤。
Tumour uptake of 11C-thymidine labeled in the methyl position was assessed after intravenous injection in 13 patients with head and neck tumours. This activity was compared to other tracers such as C15O, 13NH3 and C15O2. In every single case a 'positive' tumour image after injection of 11C-thymidine was obtained. Time-activity curves showed the initial activity to be followed by a rapid decrease over the first 10-15 min with an apparent plateau thereafter. A similar level of uptake was found in normal salivary gland regions and myocardium, while higher activities were noted in liver and kidney parenchyma. It is suggested that both blood flow and cellular metabolism can influence 11C-thymidine imaging in this class of human tumours.
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发表时间: 1987-01-23
期刊: SCIENCE
影响因子: 56.9
作者:
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通讯作者: LANGSTROM, B
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期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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