Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR.
Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR.
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DOI：
10.1371/journal.pone.0120788
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kobayashi H
中科院分区：
文献类型：
--
作者：
Komiyama T;Hirokawa T;Sato K;Oka A;Kamiguchi H;Nagata E;Sakura H;Otsuka K;Kobayashi H
本研究的目的是阐明疾病在急性应激反应中对神经介导性晕厥（NMS）的影响。我们分析了α -2肾上腺素受体（α2B-AR）基因的分子相互作用和多态性作为激励应激的潜在精神原因的机制。我们重点研究了α2B-AR基因Glu 301-303重复多态性位点的三个基因型：Glu12/12、Glu12/9和Glu9/9。根据我们的临床研究，NMS可能发生在Glu12/9异型人群中。为了验证这一点，我们通过对Glu12/9异型的硅分析评估了Gi蛋白和腺苷酸环化酶相互作用的关系。通过两次测定Gi-α亚基解离时间的差异，我们发现Glu12/9异型比Glu同型对腺苷酸环化酶的抑制时间更长。由于这种Glu重复数效应的差异被认为是NMS的原因之一，我们研究了Glu重复数的进化意义。Glu8最初是在猿类中重复的，而Glu12的重复是在人类两足动物进化过程中发生的。从Glu12数字来看，NMS可能会成为一种防御措施，以防止大量血液流向人脑。
The objective of this study was to clarify the effects of disease on neurally mediated syncope (NMS) during an acute stress reaction. We analyzed the mechanism of the molecular interaction and the polymorphisms of the alpha-2 adrenoreceptor (α2B-AR) gene as the potential psychiatric cause of incentive stress. We focused on the following three genotypes of the repeat polymorphism site at Glu 301–303 in the α2B-AR gene: Glu12/12, Glu12/9, and Glu9/9. On the basis of our clinical research, NMS is likely to occur in people with the Glu12/9 heterotype. To verify this, we assessed this relationship with the interaction of Gi protein and adenylate cyclase by in silico analysis of the Glu12/9 heterotype. By measuring the difference in the dissociation time of the Gi-α subunit twice, we found that the Glu12/9 heterotype suppressed the action of adenylate cyclase longer than the Glu homotypes. As this difference in the Glu repeat number effect is thought to be one of the causes of NMS, we investigated the evolutionary significance of the Glu repeat number. Glu8 was originally repeated in simians, while the Glu12 repeats occurred over time during the evolution of bipedalism in humans. Taken with the Glu12 numbers, NMS would likely become a defensive measure to prevent significant blood flow to the human brain.
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影响因子：
10.7
作者：
Bjork, Adam;Liu, Weimin;Worobey, Michael
通讯作者：
Worobey, Michael
DOI：
10.1007/s00586-011-1939-7
发表时间：
2011-09-01
期刊：
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
影响因子：
--
作者：
Le Huec, J C;Saddiki, R;Aunoble, S
通讯作者：
Aunoble, S
影响因子：
56.9
作者：
Arsuaga, J. L.;Martinez, I.;Carbonell, E.
通讯作者：
Carbonell, E.
影响因子：
7.6
作者：
Lei, Xuemei;Chen, Chuansheng;Dong, Qi
通讯作者：
Dong, Qi
影响因子：
64.8
作者：
Green, Richard E.;Krause, Johannes;Paeaebo, Svante
通讯作者：
Paeaebo, Svante