Hippocampal cell firing correlates of delayed-match-to-sample performance in the rat.

Hippocampal cell firing correlates of delayed-match-to-sample performance in the rat.
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海马细胞放电与大鼠的延迟匹配样本表现相关。

DOI:
10.1037//0735-7044.107.5.715
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发表时间:
1993
影响因子:
1.9
通讯作者:
Deadwyler,SA
Deadwyler,SA
中科院分区:
医学4区
文献类型:
--
作者:
Hampson,RE;Heyser,CJ;Deadwyler,SA

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记录执行延迟样本匹配 (DMTS) 任务的大鼠海马 CA1 和 CA3 神经元。复杂的尖峰细胞在样本和匹配反应之后以及在提供水奖励期间表现出显着的放电峰值。根据这 3 个阶段中每个阶段是否存在放电,单个细胞被分为 4 种亚型。 4种亚型之间的延迟间隔放电存在显着差异,但延迟期间的放电并不能预测正确的反应:34%的细胞在延迟期间的放电表现出线性变化。进一步的分析显示,无论何种亚型,大约 70% 的测试细胞存在显着的杠杆位置发射偏差。在此 DMTS 任务中记录的神经元放电相关性的复杂性表明,海马体将任务的性能需求的特定方面划分为不同的细胞亚型,这些亚型共同提供了足够的信息来解决任何给定试验中的样本匹配问题。(PsycINFO 数据库记录 (c) 2016 APA,保留所有权利)
Recorded hippocampal CA1 and CA3 neurons in rats performing a delayed-match-to-sample (DMTS) task. Complex spike cells showed significant firing peaks following sample and match responses and during delivery of water reward. Individual cells were classified into 4 subtypes according to the presence or absence of firing in each of these 3 phases. There were significant differences in delay interval firing among the 4 subtypes, but firing during the delay did not predict the correct response: 34% of the cells showed a linear change in firing during the delay. Further analyses revealed significant lever position firing biases in approximately 70% of the cells tested irrespective of subtype. The complexity of firing correlates of the neurons recorded in this DMTS task suggests that the hippocampus divides specific aspects of the performance demands of the task across different cell subtypes, which together provide sufficient information to resolve the matching-to-sample problem on any given trial.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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