A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection.
A comparative evaluation of quantitative neuroimaging measurements of brain status in HIV infection.
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DOI：
10.1016/j.pscychresns.2011.08.014
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发表时间：
2012-07-30
影响因子：
2.3
通讯作者：
Ragin, Ann B.
中科院分区：
文献类型：
--
作者：
Du, Hongyan;Wu, Ying;Ochs, Renee;Edelman, Robert R.;Epstein, Leon G.;McArthur, Justin;Ragin, Ann B.
评估体内成像参数以总结大脑与艾滋病毒感染的关系。在 10 名 HIV+ 患者和 24 名对照者中以 1.5 特斯拉实施了多参数神经成像方案。基于扩散张量成像（DTI）、磁化传递成像（MT）和自动脑容量测定计算各种汇总参数。每个测量值都确定了差异的大小以及组间歧视。计算双变量相关性并通过主因素分析检查成像参数之间的冗余。大多数措施都发现显着或接近显着的差异。大科恩 D 效应大小表示平均扩散率 (MD)、分数各向异性 (FA)、磁化传输比 (MTR) 和灰质体积分数 (GM)。 FA 和 MTR 的组间歧视非常好，而 MD 则可以接受。所有成像参数之间的相关性可以通过三个因素来解释，可能反映了全身萎缩、神经元损失和改变。这项研究支持了对艾滋病毒感染中大脑参与情况进行汇总测量的实用性。研究结果还支持有关 DTI 和 MT 对大脑萎缩和改变的敏感性增强的假设。这些发现可广泛推广到生理和病理过程的脑成像研究。
To evaluate in vivo imaging parameters for summarizing brain involvement in HIV infection. A multiparametric neuroimaging protocol was implemented at 1.5 Tesla in 10 HIV+ and 24 controls. Various summary parameters were calculated based on Diffusion Tensor Imaging (DTI), Magnetization Transfer imaging (MT) and automated brain volumetry. The magnitude of the difference, as well as the between-group discrimination, was determined for each measure. Bivariate correlations were computed and redundancy among imaging parameters was examined by principal factor analysis. Significant or nearly significant differences were found for most measures. Large Cohen’s D effect sizes were indicated for mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio (MTR) and gray matter volume fraction (GM). Between-group discrimination was excellent for FA and MTR and acceptable for MD. Correlations among all imaging parameters could be explained by three factors, possibly reflecting general atrophy, neuronal loss, and alterations. This investigation supports the utility of summary measurements of brain involvement in HIV infection. The findings also support assumptions concerning the enhanced sensitivity of DTI and MT to atrophic as well as alterations in the brain. These findings are broadly generalizable to brain imaging studies of physiological and pathological processes.
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DOI：
10.3174/ajnr.a1476
发表时间：
2009-05
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Escolar ML;Poe MD;Smith JK;Gilmore JH;Kurtzberg J;Lin W;Styner M
通讯作者：
Styner M
DOI：
10.1097/qai.0b013e318159d807
发表时间：
2007-12-15
影响因子：
3.6
作者：
Stebbins, Glenn T.;Smith, Clifford A.;Moseley, Michael E.
通讯作者：
Moseley, Michael E.
DOI：
10.1073/pnas.0502548102
发表时间：
2005-10-25
影响因子：
11.1
作者：
Thompson, PM;Dutton, RA;Becker, JT
通讯作者：
Becker, JT
影响因子：
2.3
作者：
Pomara, N;Crandall, DT;Lim, KO
通讯作者：
Lim, KO
影响因子：
--
作者：
Sevigny, Jeffrey J.;Albert, Steven M.;Epstein, Leon G.
通讯作者：
Epstein, Leon G.