Low heart rate variability and cancer-related fatigue in breast cancer survivors.
Low heart rate variability and cancer-related fatigue in breast cancer survivors.
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DOI：
10.1016/j.psyneuen.2014.03.011
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发表时间：
2014-07
影响因子：
3.7
通讯作者：
Bower, Julienne E.
中科院分区：
文献类型：
--
作者：
Crosswell, Alexandra D.;Lockwood, Kimberly G.;Ganz, Patricia A.;Bower, Julienne E.
癌症相关的疲劳是许多乳腺癌幸存者的常见症状，而且往往持续很长时间。存活者表现出炎症升高的证据，但驱动炎症活动的生理机制尚未确定。自主神经系统的改变，特别是副交感神经系统的活动，是一个合理的，但研究不足的贡献者癌症相关的疲劳。这项研究的目的是复制先前的一项研究，该研究显示乳腺癌幸存者的副交感神经活动降低与疲劳程度增加之间存在关联，并研究炎症是否介导了这种关联。研究参与者来自两个样本，包括84名最初在50岁之前被诊断为早期乳腺癌的女性。参与者完成问卷调查，提供血液样本用于测定白细胞介素（IL）-6和C反应蛋白（CRP），并进行心电图（ECG）评估以评估静息心率变异性（HRV），这是副交感神经活动的一种测量方法。结果显示，较低的HRV与较高的疲劳相关（p <0.05），正如预测的那样。在双变量分析中，HRV也与IL-6和CRP的循环浓度相关。然而，路径分析并不支持炎症作为HRV和疲劳之间关联的中介;相反，这些变量之间的关联似乎是由年龄和BMI驱动的。这些发现将HRV确定为癌症相关疲劳的潜在贡献者，但表明炎症不会介导治疗后几年的年轻健康乳腺癌幸存者的这种关联。自主神经系统在癌症相关性疲劳的病因学研究中值得额外关注。
Cancer-related fatigue is a common and often long lasting symptom for many breast cancer survivors. Fatigued survivors show evidence of elevated inflammation, but the physiological mechanisms driving inflammatory activity have not been determined. Alterations in the autonomic nervous system, and particularly parasympathetic nervous system activity, are a plausible, yet understudied contributor to cancer-related fatigue. The goal of this study was to replicate one previous study showing an association between lower parasympathetic activity and higher fatigue in breast cancer survivors, and to examine whether inflammation mediates this association. Study participants were drawn from two samples and included 84 women originally diagnosed with early-stage breast cancer prior to age 50. Participants completed questionnaires, provided blood samples for determination of interleukin (IL)-6 and C-reactive protein (CRP), and underwent electrocardiography (ECG) assessment for evaluation of resting heart rate variability (HRV), a measure of parasympathetic activity. Results showed that lower HRV was associated with higher fatigue (p < .05), as predicted. In bivariate analyses, HRV was also correlated with circulating concentrations of IL-6 and CRP. However, path analyses did not support inflammation as a mediator of the association between HRV and fatigue; instead, associations among these variables appeared to be driven by age and BMI. These findings identify HRV as a potential contributor to cancer-related fatigue, but suggest that inflammation does not mediate this association in younger, healthy breast cancer survivors who are several years post-treatment. The autonomic nervous system merits additional attention in research on the etiology of cancer-related fatigue.
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影响因子：
4.2
作者：
Donovan, Kristine A.;Small, Brent J.;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.
影响因子：
2.7
作者：
Boneva, Roumiana S.;Decker, Michael J.;Reeves, William C.
通讯作者：
Reeves, William C.
影响因子：
3.8
作者：
Groenvold, Mogens;Petersen, Morten Aagaard;Mouridsen, Henning T.
通讯作者：
Mouridsen, Henning T.
影响因子：
4.8
作者：
DEMEERSMAN, RE
通讯作者：
DEMEERSMAN, RE
影响因子：
8.2
作者：
Fritz, Matthew S.;MacKinnon, David P.
通讯作者：
MacKinnon, David P.