Long term potentiation blocked by phencyclidine and cyclazocine in vitro.
Long term potentiation blocked by phencyclidine and cyclazocine in vitro.
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在体外，苯环己哌啶和环佐辛可阻断长时程增强作用。
DOI：
10.1016/0014-2999(84)90286-3
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发表时间：
1984
影响因子：
5
通讯作者：
P. G. Guyenet
中科院分区：
文献类型：
--
作者：
J. L. Stringer;J. T. Hackett;P. G. Guyenet
在大鼠海马切片中研究了苯环己哌啶 (PCP) 和环佐辛对突触传递长期增强 (LTP) 的影响。 PCP 和环佐辛在不改变非增强突触传递的剂量下，产生 LTP 量的剂量依赖性减少。 PCP 的影响并不特定于 CA1 的 Schaffer 抵押输入； PCP 还通过刺激定向层来阻断 CA1 中诱导的 LTP。在先前在环佐辛存在下破伤风的切片中，随着药物的去除，观察到突触传递的增加； PCP 中没有出现这种情况。此外，PCP 暴露的切片洗涤 1 小时后不能产生 LTP。 PCP 剂量依赖性地逆转先前建立的 LTP，但高达 500 μM 的环佐辛却未能做到这一点。总之，PCP 和环佐辛在不影响非增强突触传递的浓度下选择性阻断 LTP。这两种药物的作用机制可能有所不同，因为只有 PCP 能够消除先前增强的反应。
The effects of phencyclidine (PCP) and cyclazocine on long-term potentiation of synaptic transmission (LTP) were studied in the rat hippocampal slice. PCP and cyclazocine, at doses which did not alter non-potentiated synaptic transmission, produced a dose-dependent reduction in the amount of LTP. The effect of PCP is not specific for the Schaffer collateral input to CA1; PCP also blocks the LTP induced in CA1 by stimulating the stratum oriens. In slices previously tetanized in the presence of cyclazocine, an increase in synaptic transmission was observed as the drug was removed; this was not seen with PCP. Moreover, LTP could not be produced in PCP-exposed slices after washing for 1 h. PCP dose-dependently reversed previously established LTP, but cyclazocine, up to 500 μM, failed to do so. In conclusion, both PCP and cyclazocine selectively block LTP at concentrations which do not affect non-potentiated synaptic transmission. The two drugs may differ in their mechanism of action since only PCP is able to eliminate a previously potentiated response.
纳洛酮的辨别刺激特性。
影响因子：
3.4
作者：
Carter,RB;Leander,JD
通讯作者：
Leander,JD
大鼠海马去甲肾上腺素能反应：体外切片中直接和间接作用的拟交感神经药的电生理作用。
DOI：
--
发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Mueller,AL;Kirk,KL;Hoffer,BJ;Dunwiddie,TV
通讯作者：
Dunwiddie,TV
苯环己哌啶的行为影响可能是由于其阻断钾通道。
DOI：
10.1073/pnas.78.12.7792
发表时间：
1981
影响因子：
11.1
作者：
Albuquerque,EX;Aguayo,LG;Warnick,JE;Weinstein,H;Glick,SD;Maayani,S;Ickowicz,RK;Blaustein,MP
通讯作者：
Blaustein,MP