Immunomodulatory effects of adipose-derived stem cells: fact or fiction?
Immunomodulatory effects of adipose-derived stem cells: fact or fiction?
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DOI：
10.1155/2013/383685
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发表时间：
2013
影响因子：
--
通讯作者：
Brandacher G
中科院分区：
文献类型：
--
作者：
Leto Barone AA;Khalifian S;Lee WP;Brandacher G
脂肪来源的基质细胞（ASC）通常被称为脂肪来源的干细胞，因为它们具有多向分化的潜力。它们在组织工程中的有前途的作用和调节免疫系统的能力是广泛研究的焦点。目前正在进行一些使用ASC的临床试验，以更好地了解这种细胞生态位在增强或抑制免疫反应中的作用。如果是可控制的，这种免疫调节作用将在存在免疫应答的几种情况下得到应用（即，自身免疫状况）或害怕（即，实体器官或重建移植）。虽然同种异体ASC在临床前和临床研究中都显示出预防急性GvHD，但其潜力值得进一步研究。精心设计和标准化的临床试验是必要的，以证明ASCs在治疗免疫疾病或预防组织排斥反应中的作用。在本文中，我们分析了目前的文献中的作用，ASCs在体外和体内的免疫调节，并讨论其在移植的背景下调节免疫系统的潜力。
Adipose-derived stromal cells (ASCs) are often referred to as adipose-derived stem cells due to their potential to undergo multilineage differentiation. Their promising role in tissue engineering and ability to modulate the immune system are the focus of extensive research. A number of clinical trials using ASCs are currently underway to better understand the role of such cell niche in enhancing or suppressing the immune response. If governable, such immunoregulatory role would find application in several conditions in which an immune response is present (i.e., autoimmune conditions) or feared (i.e., solid organ or reconstructive transplantation). Although allogeneic ASCs have been shown to prevent acute GvHD in both preclinical and clinical studies, their potential warrants further investigation. Well-designed and standardized clinical trials are necessary to prove the role of ASCs in the treatment of immune disorders or prevention of tissue rejection. In this paper we analyze the current literature on the role of ASCs in immunomodulation in vitro and in vivo and discuss their potential in regulating the immune system in the context of transplantation.
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影响因子：
24
作者：
Hare, Joshua M.;Traverse, Jay H.;Henry, Timothy D.;Dib, Nabil;Strumpf, Robert K.;Schulman, Steven P.;Gerstenblith, Gary;DeMaria, Anthony N.;Denktas, Ali E.;Gammon, Roger S.;Hermiller, James B., Jr.;Reisman, Mark A.;Schaer, Gary L.;Sherman, Warren
通讯作者：
Sherman, Warren
影响因子：
5.2
作者：
Djouad, Farida;Charbonnier, Louis-Marie;Noel, Daniele
通讯作者：
Noel, Daniele
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
3.3
作者：
Crop, Meindert J.;Korevaar, Sander S.;Hoogduijn, Martin J.
通讯作者：
Hoogduijn, Martin J.
影响因子：
1.3
作者：
Fang, Baijun;Song, Yongping;Ma, Yuanfang
通讯作者：
Ma, Yuanfang