Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy.
Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy.
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DOI：
10.3389/fendo.2022.846226
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发表时间：
2022
影响因子：
5.2
通讯作者：
Petroff, Margaret G.
中科院分区：
文献类型：
--
作者：
Ahn, Soo Hyun;Nguyen, Sean L.;Kim, Tae Hoon;Jeong, Jae-Wook;Arora, Ripla;Lydon, John P.;Petroff, Margaret G.
孕激素是一种性腺促孕激素，是怀孕成功绝对必要的。孕酮最显著的作用是在女性生殖器官、子宫和卵巢中观察到的。孕酮通过核孕酮受体（PGR）起作用，使子宫内膜为胚胎着床做好准备。有趣的是，母体胸腺也是Pgr的已知表达者;其缺失与小鼠妊娠并发症相关。然而，其表达的定位及其功能重要性尚不清楚。在这里，我们使用了转基因双荧光报告小鼠模型和Foxn 1+胸腺上皮细胞（TEC）中Pgr的遗传缺失，以证明TEC特异性Pgr在妊娠中的表达，特别是在胸腺细胞成熟发生的皮质中。使用我们的TEC-特异性Pgr缺失小鼠模型，我们证明TEC-特异性Pgr是妊娠诱导的胸腺退化在怀孕期间所必需的。我们的研究表明，PGR表达上调皮质胸腺上皮细胞在怀孕期间，PGR表达是重要的胸腺退化在小鼠怀孕期间。
Progesterone is a gonadal pro-gestational hormone that is absolutely necessary for the success of pregnancy. Most notable actions of progesterone are observed in the female reproductive organs, the uterus and the ovary. Acting through the nuclear progesterone receptor (PGR), progesterone prepares the endometrium for implantation of the embryo. Interestingly, the maternal thymus also is a known expressor of Pgr; its absence is associated with murine pregnancy complications. However, the localization of its expression and its functional importance were not known. Here, we used a transgenic dual fluorescent reporter mouse model and genetic deletion of Pgr in Foxn1+ thymic epithelial cells (TEC) to demonstrate TEC-specific Pgr expression in pregnancy, especially in the cortex where thymocyte maturation occurs. Using our TEC-specific Pgr deletion mouse model, we demonstrate that TEC-specific Pgr is necessary for pregnancy-induced thymic involution in pregnancy. Our investigation reveals that PGR expression is upregulated in the cortical thymic epithelial cells during pregnancy, and that PGR expression is important for thymic involution during murine pregnancy.
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