Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation.
Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation.
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DOI：
10.1016/j.atherosclerosis.2018.09.040
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发表时间：
2019-03
期刊：
影响因子：
5.3
通讯作者：
Reilly MP
中科院分区：
文献类型：
--
作者：
Zhang X;Li DY;Reilly MP
长基因间非编码RNA（lincRNA）越来越多地被认为是与人类病理生理学（包括心血管疾病）相关的许多生物过程的重要介质。体外研究为越来越多的lincRNA提供了细胞功能和机制的重要知识。异常调节的lncRNA与细胞命运编程和发育、血管疾病、动脉粥样硬化、血脂异常和代谢综合征以及心脏病理性肥大相关。然而，个体lincRNA在生理和疾病状态下的功能性询问在很大程度上是有限的。lincRNA作用的复杂性质和人类lincRNA的物种保守性差对动物模型系统和临床转化中的生理学研究提出了实质性挑战。本文综述了近年来在心血管疾病背景下的lincRNA生理学研究成果，包括MALAT 1、MeXis、Lnc-DC等，探讨了lincRNA作用的复杂机制，综述了描述lincRNA功能的体内研究策略，并强调了灵长类特异性lincRNA生理学研究的挑战和方法。
Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as important mediators of many biological processes relevant to human pathophysiologies, including cardiovascular diseases. In vitro studies have provided important knowledge of cellular functions and mechanisms for an increasing number of lincRNAs. Dysregulated lncRNAs have been associated with cell fate programming and development, vascular diseases, atherosclerosis, dyslipidemia and metabolic syndrome, and cardiac pathological hypertrophy. However, functional interrogation of individual lincRNAs in physiological and disease states is largely limited. The complex nature of lincRNA actions and poor species conservation of human lincRNAs pose substantial challenges to physiological studies in animal model systems and in clinical translation. This review summarizes recent findings of specific lincRNA physiological studies, including MALAT1, MeXis, Lnc-DC and others, in the context of cardiovascular diseases, examines complex mechanisms of lincRNA actions, reviews in vivo research strategies to delineate lincRNA functions and highlights challenges and approaches for physiological studies of primate-specific lincRNAs.
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影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
64.5
作者：
Atianand MK;Hu W;Satpathy AT;Shen Y;Ricci EP;Alvarez-Dominguez JR;Bhatta A;Schattgen SA;McGowan JD;Blin J;Braun JE;Gandhi P;Moore MJ;Chang HY;Lodish HF;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
64.8
作者：
Engreitz JM;Haines JE;Perez EM;Munson G;Chen J;Kane M;McDonel PE;Guttman M;Lander ES
通讯作者：
Lander ES
影响因子：
6.4
作者：
Cao J
通讯作者：
Cao J
DOI：
10.1126/science.aad0467
发表时间：
2016-04-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Castellanos-Rubio A;Fernandez-Jimenez N;Kratchmarov R;Luo X;Bhagat G;Green PH;Schneider R;Kiledjian M;Bilbao JR;Ghosh S
通讯作者：
Ghosh S