The functional role of long non-coding RNAs and epigenetics.

The functional role of long non-coding RNAs and epigenetics.
复制标题

DOI:
10.1186/1480-9222-16-11
复制
发表时间:
2014
影响因子:
6.4
通讯作者:
Cao J
Cao J
中科院分区:
生物学3区
文献类型:
--
作者:
Cao J

文献摘要

参考文献

被引文献

相似文献

长非编码 RNA (lncRNA) 是长度超过 200 个核苷酸的非蛋白质编码转录物。这些 lncRNA 通过干扰 microRNA 途径来影响转录后调节,参与多种细胞过程。 lncRNA在表观遗传水平、转录水平和转录后水平对基因表达的调控已众所周知并得到广泛研究。近年来认识到lncRNA在干细胞多能性、神经发生、肿瘤发生等多种生物学和病理过程中发挥作用。本文将重点对lncRNA在表观遗传学中的功能作用及相关研究进展进行综述。
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized.
DOI: 10.1038/onc.2011.193
发表时间: 2011-11-24
期刊: ONCOGENE
影响因子: 8
作者:
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者: Patel, T.
DOI: 10.1126/science.1112014
发表时间: 2005-09-02
期刊: SCIENCE
影响因子: 56.9
作者:
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者: Hayashizaki, Y
DOI: 10.1371/journal.pgen.1001233
发表时间: 2010-12-02
期刊: PLoS genetics
影响因子: 4.5
作者:
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者: Sharpless NE
DOI: 10.1093/hmg/dds247
发表时间: 2012-10-01
影响因子: 3.5
作者:
Brose, Rebecca Deering;Shin, Gloria;Smith, Kirby D.
通讯作者: Smith, Kirby D.
DOI: 10.1126/science.1240925
发表时间: 2013-08-16
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者: Fitzgerald KA