Prenatal exposure to moderate levels of ethanol can have long-lasting effects on learning and memory in adult offspring
Prenatal exposure to moderate levels of ethanol can have long-lasting effects on learning and memory in adult offspring
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产前接触中等水平的乙醇会对成年后代的学习和记忆产生长期影响
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
D. Savage
中科院分区：
文献类型：
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作者：
R. Sutherland;R. J. McDonald;D. Savage
产前酒精暴露会对儿童造成长期的认知和学习障碍。先前的研究表明，产前乙醇暴露会导致海马形成中的神经化学异常。我们研究了莫里斯水任务（Morris water task）的表现是否会影响怀孕期间饮用适量乙醇的大鼠后代的海马功能干扰。大鼠在整个妊娠期间食用三种饮食中的一种：(1)Bio-Serve含5%乙醇（v/v; 26% EDC）的液体饮食，母体血液乙醇浓度峰值为100 mg/dl；(2)饲喂等量0%乙醇液体饲粮；或(3)实验室饲料AD自由。来自三种母亲饮食条件下的成年后代接受莫里斯水任务三种版本之一的训练。我们使用了“标准的”固定隐藏平台任务，移动平台任务，以及测量线索和地点导航之间竞争的任务。所有三组在固定的隐藏平台版本中都学会了正常导航，并且在无平台探针试验中表现出对目标位置的明确偏好。相比之下，在移动平台版本和线索与地点竞争任务中，产前暴露大鼠相对于其他两种母亲饮食条件的大鼠出现异常。在这两项任务中，它们的行为方式与这样一种观点一致，即获取新位置信息的过程不像正常大鼠那样有效。这些数据与一种假设是一致的，即海马回路和与突触可塑性相关的神经化学是产前酒精暴露的一些长期有害认知影响的重要目标。
Prenatal alcohol exposure can produce long-lasting cognitive and learning impairments in children. Previous studies have suggested that prenatal ethanol exposure can produce neurochemical abnormalities in hippocampal formation. We examined whether performance in the Morris water task, known to be sensitive to interference with hippocampal function, would be affected in adult offspring of rat dams who consumed moderate levels of ethanol through pregnancy. Rat dams consumed one of three diets throughout gestation: (1) Bio-Serve liquid diet containing 5% ethanol (v/v; 26% EDC), which produces a maternal peak blood ethanol concentration of 100 mg/dl; (2) pair fed an isocalorically equivalent amount of 0% ethanol liquid diet; or (3) laboratory chow ad libitum. Adult offspring from each of the three maternal diet conditions were trained in one of three versions of the Morris water task. We employed the “standard” fixed hidden platform task, the moving platform task, and a task that measures competition between cue and place navigation. All three groups learned to navigate normally in the fixed hidden platform version and showed clear preferences for the goal location during no-platform probe trials. In contrast, in the moving platform version and the cue versus place competition task, the prenatally exposed rats were abnormal relative to the rats of the other two maternal diet conditions. In both of these tasks, they behaved in a manner consistent with the idea that acquisition of new place information does not proceed as effectively as in normal rats. These data are consistent with the hypothesis that hippocampal circuitry and neurochemistry related to synaptic plasticity are important targets underlying at least some of the long-lasting deleterious cognitive effects of prenatal alcohol exposure.
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产前乙醇暴露会降低成年大鼠后代氨基酸神经递质释放的活动依赖性增强。
DOI：
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发表时间：
1998
期刊：
Alcoholism, clinical and experimental research.
影响因子：
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作者：
Savage,DD;Cruz,LL;Duran,LM;Paxton,LL
通讯作者：
Paxton,LL
产前乙醇暴露会降低 45 日龄大鼠海马 NMDA 敏感的 [3H]-谷氨酸结合位点密度。
DOI：
10.1016/0741-8329(91)90806-8
发表时间：
1991
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
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作者：
Savage,DD;Montano,CY;Otero,MA;Paxton,LL
通讯作者：
Paxton,LL
产前乙醇暴露对海马代谢型谷氨酸受体刺激的磷酸肌醇水解的剂量和年龄依赖性影响。
DOI：
10.1111/j.1530-0277.1993.tb00859.x
发表时间：
1993
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Queen,SA;Sanchez,CF;Lopez,SR;Paxton,LL;Savage,DD
通讯作者：
Savage,DD
产前乙醇暴露对成年大鼠后代海马和内侧额叶皮层磷脂酶 C-β 1 和磷脂酶 A2 的影响。
DOI：
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发表时间：
1997
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Allan,AM;Weeber,EJ;Savage,DD;Caldwell,KK
通讯作者：
Caldwell,KK