Prenatal ethanol exposure decreases hippocampal NMDA-sensitive [3H]-glutamate binding site density in 45-day-old rats.
Prenatal ethanol exposure decreases hippocampal NMDA-sensitive [3H]-glutamate binding site density in 45-day-old rats.
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产前乙醇暴露会降低 45 日龄大鼠海马 NMDA 敏感的 [3H]-谷氨酸结合位点密度。
DOI：
10.1016/0741-8329(91)90806-8
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Paxton,LL
中科院分区：
文献类型：
--
作者：
Savage,DD;Montano,CY;Otero,MA;Paxton,LL
研究了产前乙醇暴露对大鼠脑内N-甲基-D-天冬氨酸（NMDA）敏感的[3H]-谷氨酸受体结合位点密度的影响。在整个妊娠期间，给妊娠Sprague-Dawley大鼠喂食含3.35%乙醇的流质饲料。这种饮食在给予液体饮食8小时后产生约39 mg/dl的母体血液乙醇峰值水平。配对喂养的母鼠接受等热量匹配的流质饮食，随意实验室食物组作为配对喂养技术的对照组。在45天的年龄，从每个三个饮食组的后代被处死，脑NMDA敏感的[3H]-谷氨酸结合位点密度测量使用体外放射组织化学技术。与成对喂养和随意对照组相比，酒精胎鼠齿状回、海马CA1区和背侧海马结构下托的顶端树突区NMDA敏感性[3H]-谷氨酸结合位点密度显著降低19%至29%。NMDA敏感的[3H]-谷氨酸结合位点密度在腹侧海马结构、后部新皮质、外侧内嗅皮质或小脑中的三组之间没有显著差异。这些结果与之前观察到的总[3H]-谷氨酸受体结合位点密度减少的胎酒精大鼠的背海马结构，以及更多的电生理观察到的胎酒精海马切片NMDA的敏感性降低一致。
The effect of prenatal ethanol exposure on N-methyl-d-aspartate (NMDA)-sensitive [3H]-glutamate receptor binding site density was studied in rat brain. Pregnant Sprague-Dawley rats were fed a liquid diet containing 3.35% ethanol throughout gestation. This diet produced maternal peak blood ethanol levels of about 39 mg/dl eight hours after the administration of the liquid diet. Pair-fed dams received an isocalorically matched liquid diet and an ad lib lab chow group served as control for the paired feeding technique. At 45 days of age, offspring from each of the three diet groups were sacrificed and brain NMDA-sensitive [3H]-glutamate binding site density measured using in vitro radiohistochemical techniques. NMDA-sensitive [3H]-glutamate binding site density was reduced significantly by 19 to 29% in the apical dendritic field regions of dentate gyrus, hippocampal CA1and subiculum of dorsal hippocampal formation of fetal alcohol rats compared to pair-fed and ad lib controls. NMDA-sensitive [3H]-glutamate binding site density was not significantly different among the three groups in the ventral hippocampal formation, posterior neocortex, lateral entorhinal cortex or cerebellum. These results are consistent with out previous observations of a reduction in total [3H]-glutamate receptor binding site density in the dorsal hippocampal formation of fetal alcohol rats, as well as more electrophysiological observations of a decrease in the sensitivity of fetal alcohol hippocampal slices to NMDA.
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小鼠长期饮酒后海马形态的变化。
影响因子：
56.9
作者：
J. Riley;D. W. Walker
通讯作者：
D. W. Walker
硫氰酸盐可稳定 AMPA 与使君子酸受体的结合。
影响因子：
5
作者：
Nielsen,EO;Cha,JH;Honoré,T;Penney,JB;Young,AB
通讯作者：
Young,AB
通过放射受体技术进行血浆药物测定
DOI：
--
发表时间：
1983
期刊：
影响因子：
--
作者：
D. Barnett;S. Nahorski
通讯作者：
S. Nahorski
产前暴露于酒精的大鼠的反应持续
DOI：
--
发表时间：
1979
期刊：
Pharmacology, Biochemistry and Behavior
影响因子：
--
作者：
E. Riley;E. A. Lochry;N. Shapiro;J. Baldwin
通讯作者：
J. Baldwin
通过定量放射自显影确定大鼠脑中 [3H]AMPA 结合位点的分布
影响因子：
2.9
作者：
D. Monaghan;D. Yao;C. Cotman
通讯作者：
C. Cotman