Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies
Disorder strength measured by quantitative phase imaging as intrinsic cancer marker in fixed tissue biopsies
复制标题
通过定量相位成像作为固定组织活检中内在癌症标志物测量的紊乱强度
作者：
M. Takabayashi;Hassaan Majeed;A. Kajdacsy;G. Popescu
组织折射率提供了纳米尺度上形态学的重要信息。由于恶性转化涉及到折射率图中的细胞内和细胞间的变化，因此组织紊乱测量可以用来提取重要的诊断信息。定量相位成像（QPI）提供了一种实用的方法来提取这些信息，因为它通过亚波长灵敏度映射组织样品的光程长度差（OPD）。在这项工作中，我们采用QPI比较良性和恶性乳腺组织组织学样本的组织紊乱强度。我们的研究结果表明，疾病进展的标志是疾病强度的显著增加。由于我们的成像系统可以作为升级模块添加到现有的显微镜，我们预计它可以很容易地集成到病理工作流程中。
Tissue refractive index provides important information about morphology at the nanoscale. Since the malignant transformation involves both intra- and inter-cellular changes in the refractive index map, the tissue disorder measurement can be used to extract important diagnosis information. Quantitative phase imaging (QPI) provides a practical means of extracting this information as it maps the optical path-length difference (OPD) across a tissue sample with sub-wavelength sensitivity. In this work, we employ QPI to compare the tissue disorder strength between benign and malignant breast tissue histology samples. Our results show that disease progression is marked by a significant increase in the disorder strength. Since our imaging system can be added as an upgrading module to an existing microscope, we anticipate that it can be integrated easily in the pathology work flow.
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影响因子：
11.2
作者：
Uttam S;Pham HV;LaFace J;Leibowitz B;Yu J;Brand RE;Hartman DJ;Liu Y
通讯作者：
Liu Y
影响因子：
3.6
作者：
Subramanian H;Pradhan P;Liu Y;Capoglu IR;Rogers JD;Roy HK;Brand RE;Backman V
通讯作者：
Backman V
影响因子：
3.6
作者：
Ding, Huafeng;Wang, Zhuo;Popescu, Gabriel
通讯作者：
Popescu, Gabriel
影响因子：
3.5
作者：
Wang, Zhuo;Tangella, Krishnarao;Popescu, Gabriel
通讯作者：
Popescu, Gabriel
影响因子：
3.6
作者：
Wang, Zhuo;Ding, Huafeng;Popescu, Gabriel
通讯作者：
Popescu, Gabriel