Mapping Neural Activation onto Behavior in an Entire Animal
Mapping Neural Activation onto Behavior in an Entire Animal
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将神经激活映射到整个动物的行为
DOI：
10.1126/science.1253853
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发表时间：
2014
期刊：
影响因子：
56.9
通讯作者：
E. Marder
中科院分区：
文献类型：
--
作者：
Timothy O’Leary;E. Marder
技术的结合揭示了哪些神经元构成果蝇幼虫特定行为的回路。[Also参见Vogelstein等人的研究文章]近世纪来，神经科学家一直试图了解神经元活动模式如何产生行为。许多早期的研究转向无脊椎动物的“简单”系统，希望发现电路的组成部分及其连接。一个惊人的发现是存在的“命令神经元”在节肢动物和软体动物，产生复杂和协调的运动时，刺激（1，2）。接下来的挑战是确定这些神经元和其他对这些行为很重要的神经元之间的联系。这种方法总是局限于检查动物中数万或数十万个神经元中的少数神经元（3）。在本期的第386页，Vogelstein等人（4）开创了一个新的时代，即破译整个神经系统如何产生行为的综合方法。
A combination of technologies reveals which neurons constitute circuits for specific behaviors in Drosophila larvae. [Also see Research Article by Vogelstein et al.] For almost a century, neuroscientists have tried to understand how patterns of neuronal activity generate behavior. Many of the early studies turned to the “simple” systems of invertebrates in the hope of discovering the components of circuits and their connections. A striking finding was the existence of “command neurons” in arthropods and molluscs that produce complex and coordinated movements when stimulated (1, 2). The challenge was then to identify the connections between these neurons and other neurons important for those behaviors. This approach was always limited to examining only a few neurons from the tens or hundreds of thousands in the animal (3). On page 386 of this issue, Vogelstein et al. (4) usher in a new era of integrated methods for deciphering how an entire nervous system generates behavior.
影响因子：
48
作者：
Bargmann, Cornelia I.;Marder, Eve
通讯作者：
Marder, Eve