Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study.
Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study.
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DOI：
10.1186/s13058-020-01375-7
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Bernstein JL
中科院分区：
文献类型：
--
作者：
Watt GP;Sung J;Morris EA;Buys SS;Bradbury AR;Brooks JD;Conant EF;Weinstein SP;Kontos D;Woods M;Colonna SV;Liang X;Stein MA;Pike MC;Bernstein JL
Background parenchymal enhancement (BPE) on breast magnetic resonance imaging (MRI) may be associated with breast cancer risk, but previous studies of the association are equivocal and limited by incomplete blinding of BPE assessment. In this study, we evaluated the association between BPE and breast cancer based on fully blinded assessments of BPE in the unaffected breast. The Imaging and Epidemiology (IMAGINE) study is a multicenter breast cancer case-control study of women receiving diagnostic, screening, or follow-up breast MRI, recruited from three comprehensive cancer centers in the USA. Cases had a first diagnosis of unilateral breast cancer and controls had no history of or current breast cancer. A single board-certified breast radiologist with 12 years’ experience, blinded to case-control status and clinical information, assessed the unaffected breast for BPE without view of the affected breast of cases (or the corresponding breast laterality of controls). The association between BPE and breast cancer was estimated by multivariable logistic regression separately for premenopausal and postmenopausal women. The analytic dataset included 835 cases and 963 controls. Adjusting for fibroglandular tissue (breast density), age, race/ethnicity, BMI, parity, family history of breast cancer, BRCA1/BRCA2 mutations, and other confounders, moderate/marked BPE (vs minimal/mild BPE) was associated with breast cancer among premenopausal women [odds ratio (OR) 1.49, 95% CI 1.05–2.11; p = 0.02]. Among postmenopausal women, mild/moderate/marked vs minimal BPE had a similar, but statistically non-significant, association with breast cancer (OR 1.45, 95% CI 0.92–2.27; p = 0.1). BPE is associated with breast cancer in premenopausal women, and possibly postmenopausal women, after adjustment for breast density and confounders. Our results suggest that BPE should be evaluated alongside breast density for inclusion in models predicting breast cancer risk.
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DOI：
10.1158/1940-6207.capr-15-0408
发表时间：
2016-07
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Brown JC;Kontos D;Schnall MD;Wu S;Schmitz KH
通讯作者：
Schmitz KH
影响因子：
19.7
作者：
King, Valencia;Brooks, Jennifer D.;Morris, Elizabeth A.
通讯作者：
Morris, Elizabeth A.
影响因子：
3.3
作者：
Dilorenzo, Giuseppe;Telegrafo, Michele;Moschetta, Marco
通讯作者：
Moschetta, Marco
DOI：
10.5152/tjbh.2016.3247
发表时间：
2017-01-01
期刊：
JOURNAL OF BREAST HEALTH
影响因子：
--
作者：
Ozturk, Mesut;Polat, Ahmet Veysel;Polat, Ayfer Kamali
通讯作者：
Polat, Ayfer Kamali
影响因子：
3.3
作者：
Bignotti, Bianca;Calabrese, Massimo;Mariscotti, Giovanna
通讯作者：
Mariscotti, Giovanna