Liver cancer stem cells: Recent progress in basic and clinical research.
Liver cancer stem cells: Recent progress in basic and clinical research.
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DOI：
10.1016/j.reth.2021.03.002
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发表时间：
2021-06
影响因子：
4.3
通讯作者：
Kaneko S
中科院分区：
文献类型：
--
作者：
Yamashita T;Kaneko S
癌症干细胞（CSC）假说于40多年前被提出，该假说指出，肿瘤的生长是由一小部分癌细胞维持的，这些癌细胞在自我更新和分化能力方面类似于正常组织干细胞。癌症干细胞分离技术的进步最初在血液系统恶性肿瘤中取得，后来在实体肿瘤中也取得了进展，包括肝细胞癌（HCC），这是肝癌的主要组织学类型。越来越多的证据表明，肝脏癌症干细胞对肝细胞癌的肿瘤生长、转移以及化疗/放疗抗性具有重要作用，但肝脏癌症干细胞概念在肝细胞癌临床诊断和治疗中的应用尚未达到最初预期的程度。此外，最近人们注意到肝脏癌症干细胞的异质性和可塑性，这可能与耐药性以及治疗后肿瘤的快速生长和/或转移有关。在此，我们介绍我们在肝脏癌症干细胞研究方面的最新进展，并讨论其临床意义，这可能会促使肝细胞癌的诊断和治疗得到改进。
The cancer stem cell (CSC) hypothesis was proposed over 4 decades ago and states that tumor growth is maintained by a small subset of cancer cells analogous to normal tissue stem cells in terms of self-renewal and differentiation capacity. Advances in CSC isolation were initially achieved in hematological malignancies and later in solid tumors, including hepatocellular carcinoma (HCC), the major histological type of liver cancer. Increasing evidence suggests the importance of liver CSCs for tumor growth, metastasis, and chemo/radiation resistance in HCC, but the application of the liver CSC concept for the clinical diagnosis and treatment of HCC has not yet been achieved to the extent initially expected. Furthermore, the heterogeneity and plasticity of liver CSCs has recently been noted and might be related to drug resistance and the rapid growth and/or metastasis of the tumor after treatment. Here, we introduce our recent advancement in liver CSC research and discuss the clinical implications, which may lead to the development of improved diagnostics and treatment in HCC.
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DOI：
10.1002/hep.26168
发表时间：
2013-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Yamashita T;Honda M;Nakamoto Y;Baba M;Nio K;Hara Y;Zeng SS;Hayashi T;Kondo M;Takatori H;Yamashita T;Mizukoshi E;Ikeda H;Zen Y;Takamura H;Wang XW;Kaneko S
通讯作者：
Kaneko S
影响因子：
11.2
作者：
Hoshida Y;Nijman SM;Kobayashi M;Chan JA;Brunet JP;Chiang DY;Villanueva A;Newell P;Ikeda K;Hashimoto M;Watanabe G;Gabriel S;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
25.7
作者：
Nishino, Ryuhei;Honda, Masao;Kaneko, Shuichi
通讯作者：
Kaneko, Shuichi
影响因子：
2.5
作者：
Kanki, Akihiko;Tamada, Tsutomu;Ito, Katsuyoshi
通讯作者：
Ito, Katsuyoshi
影响因子：
11.2
作者：
Yamashita, Taro;Forgues, Marshorma;Wang, Xin Wei
通讯作者：
Wang, Xin Wei