Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.
Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.
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DOI：
10.1007/s00439-014-1471-z
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发表时间：
2014-11
期刊：
影响因子：
5.3
通讯作者：
Poland, Gregory A.
中科院分区：
文献类型：
--
作者：
Kennedy, Richard B.;Ovsyannikova, Inna G.;Haralambieva, Iana H.;Lambert, Nathaniel D.;Pankratz, V. Shane;Poland, Gregory A.
风疹病毒在大多数情况下会导致相对良性的疾病，尽管怀孕期间的感染可能导致严重的出生缺陷。自20世纪70年代初以来，有效的疫苗已经问世，在高度接种（≥2剂）的人群中通常不会发生疫情。尽管如此，个体间对风疹免疫的免疫应答确实存在相当大的差异，单次接种的血清转化率约为95%。了解这种变异性背后的机制可能为风疹免疫提供重要的见解。在目前的研究中，我们研究了选定的细胞因子，细胞因子受体和先天性/抗病毒基因和风疹疫苗接种后的免疫反应，以了解遗传对疫苗反应的影响之间的关联单核苷酸多态性（SNP）。我们的方法包括一个由887名年龄在11-22岁的受试者组成的发现队列和一个由542名年龄较大的青少年和年轻人（18-40岁）组成的复制队列。我们的数据表明，亲丁酸蛋白基因（BTN 3A 3/BTN 2A 1）和细胞因子受体（IL 10 RB/IFNAR 1）附近的SNP与IFNγ分泌的变化相关，PVR基因中的多个SNP以及位于阿达尔基因中的SNP与风疹病毒特异性IL-6分泌显著相关。这些信息可能是有用的，不仅在进一步了解风疹疫苗的免疫反应，但也在确定关键途径，有针对性的佐剂使用，以提高免疫力弱或缺乏免疫接种后。
Rubella virus causes a relatively benign disease in most cases, although infection during pregnancy can result in serious birth defects. An effective vaccine has been available since the early 1970s and outbreaks typically do not occur among highly vaccinated (≥2 doses) populations. Nevertheless, considerable inter-individual variation in immune response to rubella immunization does exist, with single dose seroconversion rates ~95%. Understanding the mechanisms behind this variability may provide important insights into rubella immunity. In the current study, we examined associations between single nucleotide polymorphisms (SNPs) in selected cytokine, cytokine receptor, and innate/antiviral genes and immune responses following rubella vaccination in order to understand genetic influences on vaccine response. Our approach consisted of a discovery cohort of 887 subjects ages 11–22 at the time of enrollment and a replication cohort of 542 older adolescents and young adults (ages 18–40). Our data indicate that SNPs near the butyrophilin genes (BTN3A3/BTN2A1) and cytokine receptors (IL10RB/IFNAR1) are associated with variations in IFNγ secretion and that multiple SNPs in the PVR gene, as well as SNPs located in the ADAR gene, exhibit significant associations with rubella virus-specific IL-6 secretion. This information may be useful, not only in furthering our understanding immune responses to rubella vaccine, but also in identifying key pathways for targeted adjuvant use to boost immunity in those with weak or absent immunity following vaccination.
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影响因子：
3.2
作者：
Dhiman, Neelam;Haralambieva, Iana H.;Kennedy, Richard B.;Vierkant, Robert A.;O'Byrne, Megan M.;Ovsyannikova, Inna G.;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
2.7
作者：
Ovsyannikova, IG;Jacobson, RM;Poland, GA
通讯作者：
Poland, GA
影响因子：
5.3
作者：
Ovsyannikova IG;Dhiman N;Haralambieva IH;Vierkant RA;O'Byrne MM;Jacobson RM;Poland GA
通讯作者：
Poland GA
影响因子：
6.4
作者：
Ovsyannikova, Inna G.;Haralambieva, Iana H.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
6.4
作者：
Ovsyannikova, Inna G.;Vierkant, Robert A.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.