Myocardial function and metabolism in pig hearts after relief from chronic partial coronary stenosis.
Myocardial function and metabolism in pig hearts after relief from chronic partial coronary stenosis.
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慢性部分冠状动脉狭窄缓解后猪心脏的心肌功能和代谢。
DOI：
10.1152/ajpheart.1994.267.4.h1312
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Subramanian,R
中科院分区：
文献类型：
--
作者：
Liedtke,AJ;Renstrom,B;Nellis,SH;Subramanian,R
比较8只猪心脏（RCS组）去除慢性4天部分冠状动脉狭窄后急性体外再灌注期间的代谢行为，以及7只长期制备心脏（Sham组）的类似体外再灌注期间的代谢行为。RCS心脏的左前降支（LAD）冠状动脉狭窄是通过液压闭塞器的部分膨胀来诱导的，以限制LAD峰值相速度约50%。慢性冠状动脉狭窄4天后，RCS与假手术心脏相比，局部机械缩短减少[收缩缩短（P < 0.066），收缩扩张（P < 0.015）]，但与假手术心脏在狭窄缓解后相当。在再灌注时类似的负荷（左心室压和心率）下，两组之间的代谢行为是不同的。具体来说，与假心脏相比，RCS心脏的心肌氧消耗选择性增加（+ 49 δ %, P < 0.026）， [U-14C]棕榈酸盐产生的14CO2估计的脂肪酸氧化（+ 60 δ %, P < 0.061）和[5-3H]葡萄糖释放的3H2O测量的外源性葡萄糖利用率（+ 517 δ %, P < 0.025）。在研究结束时，三苯四唑氯染色未显示RCS或Sham心脏大梗死的明显证据，两组心肌前壁显微镜下坏死的组织学调查基本不显著。氧气消耗水平和首选脂肪酸利用的保存表明，在慢性冠状动脉部分狭窄切除后的早期恢复中，代谢保持或恢复其有氧活动模式。（摘要删节250字）
Metabolic behavior was compared during acute extracorporeal reperfusion after removal of a chronic 4-day partial coronary stenosis in eight pig hearts (RCS group) and during comparable extracorporeal perfusion in seven chronically prepared hearts (Sham group). Coronary stenosis in RCS hearts was induced in the left anterior descending (LAD) artery by partial inflation of a hydraulic occluder to restrict LAD peak phasic velocity by approximately 50%. Regional mechanical shortening was decreased in RCS compared with Sham hearts after 4 days of chronic coronary stenosis [diminished systolic shortening (P < 0.066) with systolic expansion (P < 0.015)] but was comparable to Sham hearts after relief from stenosis. At analogous workloads (left ventricular pressure and heart rate) during reperfusion, metabolic behavior was distinctive between groups. Specifically, compared with Sham hearts, myocardial O2 consumption was selectively increased in RCS hearts (+ 49 delta %, P < 0.026) as was fatty acid oxidation estimated from 14CO2 production from [U-14C]palmitate (+ 60 delta %, P < 0.061) and exogenous glucose utilization measured from the release of 3H2O from [5-3H]glucose (+ 517 delta %, P < 0.025). At the conclusion of the studies, triphenyltetrazolium chloride staining showed no gross evidence of macroinfarction in RCS or Sham hearts, and there was an essentially unremarkable histological survey of anterior myocardium for microscopic necrosis in either group. The level of O2 consumption and preservation of preferred fatty acid utilization indicate that metabolism remains or regains its aerobic pattern of activity in early recovery immediately after removal of chronic partial coronary stenosis.(ABSTRACT TRUNCATED AT 250 WORDS)
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发表时间：
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DOI：
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发表时间：
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