A serotonin agonist phase-shifts the circadian clock in the suprachiasmatic nuclei in vitro
A serotonin agonist phase-shifts the circadian clock in the suprachiasmatic nuclei in vitro
复制标题
血清素激动剂在体外使视交叉上核的生物钟发生相移
DOI：
10.1016/0006-8993(90)90153-3
复制
发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
H. Heller
中科院分区：
文献类型：
--
作者：
R. Prosser;Joseph D. Miller;H. Heller
哺乳动物视交叉上核（SCN）的昼夜节律起搏器接受来自中缝核的大量5-HT能投射。SCN起搏器是否可以通过这种传入投射来调制，这是一个具有相当大的理论和实际意义的问题。在这项研究中，我们调查是否5-HT激动剂，quipazine，可以重置的SCN时钟的相位时，它是在体外分离。我们的研究结果表明，1小时的治疗与quipqzine诱导强大的相移在体外，这种效果取决于治疗的circadain时间。我们进一步表明，quipazine诱导相移的能力是剂量依赖性的。这些结果表明，SCN的昼夜节律起搏器是敏感的5-HTergic刺激，因此，5-HTergic投射到SCN可能发挥作用，在调制的相位SCN时钟在完整的动物。
The mammalian circadian pacemaker in the suprachiasmatic nuclei (SCN) receives a large serotonergic (5-HTergic) projection from the raphe nuclei. Whether the SCN pacemaker can be modulated by this afferent projection is a question of considerable theoretical and practical interest. In this study we investigated whether the 5-HT agonist, quipazine, can reset the phase of the SCN clock when it is isolated in vitro. Our results show that 1 h treatments with quipqzine induce robust phase shifts in vitro, and that this effect depends upon the circadain time of treatment. We further show that the ability of quipazine to induce phase shifts is dose-dependent. These results suggest that the SCN circadian pacemaker is sensitive to 5-HTergic stimulation, and therefore that the 5-HTergic projection to the SCN may play a role in modulating the phase of the SCN clock in the intact animal.
体内 5-羟基色胺末端输出 5-羟基吲哚乙酸的性质和大小与视交叉上核的特定区域有关。
影响因子：
4.1
作者：
Ramirez,AD;Ramirez,VD;Meyer,DC
通讯作者：
Meyer,DC