Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection.
Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection.
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DOI：
10.1371/journal.pone.0016130
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发表时间：
2011-01-10
期刊：
影响因子：
3.7
通讯作者：
Joloba ML
中科院分区：
文献类型：
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作者：
Lukoye D;Cobelens FG;Ezati N;Kirimunda S;Adatu FE;Lule JK;Nuwaha F;Joloba ML
撒哈拉以南非洲结核病患者的耐药性正在增加，这可能是由于与艾滋病毒感染有关。我们研究了在乌干达坎帕拉诊断的533例涂阳肺结核患者的代表性样本中的耐药性和HIV感染。在473例新患者中，5例（1.1%，95%CI 0.3-2.5）发现多药耐药，57例（12.1%，9.3-15.3）发现对任何药物耐药。在60例既往接受过治疗的患者中，分别为7例（11.7%，4.8-22.6）和17例（28.3%; 17.5-41.4）。在517例有HIV结果的患者中，165例（31.9%，27.9-36.1）检测为阳性。多药治疗（校正比值比（ORadj）0.7; 95% CI 0.19-2.6）和任何耐药（ORadj 0.7; 0.43-1.3）均与HIV状态无关。对任何药物的原发性耐药在曾从事医疗保健工作的患者中更常见（ORadj 3.5; 1.0-12.0）。坎帕拉的抗结核药物耐药率较低，与艾滋病毒感染无关，但可能与卫生保健期间的接触有关。
Drug resistance among tuberculosis patients in sub-Saharan Africa is increasing, possibly due to association with HIV infection. We studied drug resistance and HIV infection in a representative sample of 533 smear-positive tuberculosis patients diagnosed in Kampala, Uganda. Among 473 new patients, multidrug resistance was found in 5 (1.1%, 95% CI 0.3–2.5) and resistance to any drug in 57 (12.1%, 9.3–15.3). Among 60 previously treated patients this was 7 (11.7%, 4.8–22.6) and 17 (28.3%; 17.5–41.4), respectively. Of 517 patients with HIV results, 165 (31.9%, 27.9–36.1) tested positive. Neither multidrug (adjusted odds ratio (ORadj) 0.7; 95% CI 0.19–2.6) nor any resistance (ORadj 0.7; 0.43–1.3) was associated with HIV status. Primary resistance to any drug was more common among patients who had worked in health care (ORadj 3.5; 1.0–12.0). Anti-tuberculosis drug resistance rates in Kampala are low and not associated with HIV infection, but may be associated with exposure during health care.
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影响因子：
168.9
作者：
Wright, Abigail;Zignol, Matteo;Raviglione, Mario
通讯作者：
Raviglione, Mario
影响因子：
3.7
作者：
Suchindran S;Brouwer ES;Van Rie A
通讯作者：
Van Rie A
DOI：
10.1086/592252
发表时间：
2008-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Temple B;Ayakaka I;Ogwang S;Nabanjja H;Kayes S;Nakubulwa S;Worodria W;Levin J;Joloba M;Okwera A;Eisenach KD;McNerney R;Elliott AM;Smith PG;Mugerwa RD;Ellner JJ;Jones-López EC
通讯作者：
Jones-López EC
影响因子：
168.9
作者：
Gandhi, Neel R.;Moll, Anthony;Friedland, Gerald
通讯作者：
Friedland, Gerald
DOI：
10.1097/00126334-200104010-00006
发表时间：
2001-04-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
Girardi, E;Palmieri, F;Ippolito, G
通讯作者：
Ippolito, G