The Ras/MAPK pathway is required for generation of iNKT cells.
The Ras/MAPK pathway is required for generation of iNKT cells.
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DOI：
10.1371/journal.pone.0019890
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发表时间：
2011-05-10
期刊：
影响因子：
3.7
通讯作者：
Alberola-Ila J
中科院分区：
文献类型：
--
作者：
Hu T;Gimferrer I;Simmons A;Wiest D;Alberola-Ila J
iNKT cells derive from CD4+CD8+ DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to this process. Surprisingly, current models imply that the Ras/MAPK pathway, one of the critical mediators of conventional αβ T cell positive selection, is not necessary for iNKT cell development. Using mice defective at different levels of this pathway our results refute this paradigm, and demonstrate that Ras, and its downstream effectors Egr-1 and Egr-2 are required for positive selection of iNKT cells. Interestingly our results also show that there are differences in the contributions of several of these molecules to the development of iNKT and conventional αβ T cells.
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DOI：
10.4049/jimmunol.181.11.7778
发表时间：
2008-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lauritsen JP;Kurella S;Lee SY;Lefebvre JM;Rhodes M;Alberola-Ila J;Wiest DL
通讯作者：
Wiest DL
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DOI：
10.1084/jem.20042432
发表时间：
2005-03-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Pasquier B;Yin L;Fondanèche MC;Relouzat F;Bloch-Queyrat C;Lambert N;Fischer A;de Saint-Basile G;Latour S
通讯作者：
Latour S
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
11.4
作者：
SWAN, KA;ALBEROLAILA, J;PERLMUTTER, RM
通讯作者：
PERLMUTTER, RM
影响因子：
4.4
作者：
Bettini, M;Xi, HK;Kersh, GJ
通讯作者：
Kersh, GJ