Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing.
Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing.
复制标题
急性非淋巴细胞白血病、白血病前期和继发于其他恶性疾病治疗的急性骨髓增生综合征。
作者：
J. Pedersen‐Bjergaard;P. Philip;B. Mortensen;J. Ersbøll;G. Jensen;J. Panduro;M. Thomsen
对 31 名患有白血病前期、急性骨髓增生综合征的患者进行了研究。或因淋巴细胞增殖性疾病、多发性骨髓瘤或实体瘤而进行放射和/或化疗后明显的急性非淋巴细胞白血病。 28 名患者的原发肿瘤已完全缓解。所有患者均出现白细胞增多或不明原因的血细胞减少。初步检查显示，5 名患者患有明显的急性非淋巴细胞白血病，5 名患者患有急性骨髓增殖综合征，21 名患者患有白血病前期。随访期间。 1 6/21 白血病前期患者出现急性骨髓增生或明显白血病。 26/31 名患者观察到骨髓克隆细胞遗传学异常。 21个是亚二倍体。所有异常克隆显然都缺乏 B 或 C 组染色体。条带技术揭示了四个异常为5q。 5 合一。
Thirty-one patients were studied with a clinical picture of preleukemia, acute myeloproliferative syndrome. or overt acute nonlymphocytic leukemia following irradiation and/ or chemotherapy for lymphoproliferative disorders, multipIe myeloma, or solid tumors. In 28 patients the original tumor was in complete remission. All patients had developed leukocytosis or unexplained cytopenia. The initial examinations disclosed overt acute nonlymphocytic leukemia in 5, acute myeloproliferative syndrome in 5, and preleukemia in 21 patients. During the follow-up period. acute myeloproliferation or overt leukemia developed in 1 6/21 preleukemic patients. Clonal cytogenetic abnormalities in the bone marrow were observed in 26/31 patients. 21 were hypodiploid. and all abnormal clones apparently were lacking a B or C group chromosome. Banding technique disclosed the abnormality as 5q in four. 5 in one.
影响因子：
3.1
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman