Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
复制标题
利钠肽受体 C 的缺失可减轻高胆固醇血症载脂蛋白 E 敲除小鼠的脂肪组织炎症
DOI：
10.1111/jcmm.16931
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发表时间：
2021-10
影响因子：
5.3
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Cheng C;Xue F;Sui W;Meng L;Xie L;Zhang C;Yang J;Zhang Y
脂肪组织炎症是动脉粥样硬化最常见的继发性病变之一，并影响动脉粥样硬化的进程。利钠肽在调节脂肪代谢中具有重要作用。然而，利钠肽受体C与动脉粥样硬化中脂肪组织炎症的关系仍不清楚。本研究旨在探讨利钠肽C受体对西式饮食诱导的动脉粥样硬化小鼠脂肪炎症的调节作用及其机制。为了阐明NPRC在动脉粥样硬化小鼠脂肪炎症中的重要性，在喂食普通饲料和西式饲料12周的小鼠中测量了NPRC表达，我们发现动脉粥样硬化小鼠的脂肪组织显著增加。将小鼠中的整体NPRC敲除与ApoE−/−小鼠交配以产生NPRC−/−ApoE−/−小鼠，其显示白色脂肪组织的布朗宁和脂肪组织的脂解显著增加，并且脂肪炎症减少，表现为巨噬细胞侵袭减少以形成较少的CLS（冠状结构），减少氧化应激，减轻TNFα、IL-6、IL-1β和MCP 1的表达，但增加脂肪组织中脂联素的表达。此外，我们的研究表明，NPRC-/-Apoe-/-动脉粥样硬化小鼠的白色脂肪组织布朗宁与通过cAMP/PKA信号传导激活降低的炎症反应有关。这些结果确定NPRC作为动脉粥样硬化小鼠脂肪炎症的新型调节剂，通过调节白色脂肪组织布朗宁。
The inflammation of adipose tissue is one of the most common secondary pathological changes in atherosclerosis, which in turn influences the process of atherosclerosis. Natriuretic peptides have been revealed important effect in regulating adipose metabolism. However, the relationship between natriuretic peptide receptor C and inflammation of adipose tissue in atherosclerosis remains unknown. This study aims to explore the effect natriuretic peptide receptor C exerts on the regulation of the adipose inflammation in atherosclerotic mice induced by western‐type diet and its overlying mechanisms. To clarify the importance of NPRC of adipose inflammation in atherosclerotic mice, NPRC expression was measured in mice fed with chow diet and western‐type diet for 12 weeks and we found a considerable increase in adipose tissue of atherosclerotic mice. Global NPRC knockout in mice was bred onto ApoE−/− mice to generate NPRC−/−ApoE−/− mice, which displayed remarked increase in browning of white adipose tissue and lipolysis of adipose tissue and decrease in adipose inflammation manifested by decreased macrophage invasion to form less CLS (crown‐like structure), reduced oxidative stress and alleviated expression of TNFα, IL‐6, IL‐1β and MCP1, but increased expression of adiponectin in adipose tissue. Moreover, our study showed that white adipose tissue browning in NPRC−/−ApoE−/− atherosclerotic mice was associated with decreased inflammatory response through cAMP/PKA signalling activation. These results identify NPRC as a novel regulator for adipose inflammation in atherosclerotic mice by modulating white adipose tissue browning.
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DOI：
10.1530/joe-13-0339
发表时间：
2014-02
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Cao H
通讯作者：
Cao H
影响因子：
16.6
作者：
Berbée JF;Boon MR;Khedoe PP;Bartelt A;Schlein C;Worthmann A;Kooijman S;Hoeke G;Mol IM;John C;Jung C;Vazirpanah N;Brouwers LP;Gordts PL;Esko JD;Hiemstra PS;Havekes LM;Scheja L;Heeren J;Rensen PC
通讯作者：
Rensen PC
影响因子：
5.6
作者：
He, Xiao-lin;Dukkipati, Abhiram;Garcia, K. Christopher
通讯作者：
Garcia, K. Christopher
影响因子：
7.7
作者：
Iwaki, M;Matsuda, M;Shimomura, I
通讯作者：
Shimomura, I
DOI：
10.1161/01.atv.0000173306.47722.ec
发表时间：
2005-08-01
影响因子：
8.7
作者：
Bodary, PF;Gu, SF;Eitzman, DT
通讯作者：
Eitzman, DT