Comparison of outcomes in adults with pediatric-onset morphea and those with adult-onset morphea: a cross-sectional study from the morphea in adults and children cohort.
Comparison of outcomes in adults with pediatric-onset morphea and those with adult-onset morphea: a cross-sectional study from the morphea in adults and children cohort.
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DOI：
10.1002/art.38853
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发表时间：
2014-12
影响因子：
13.3
通讯作者：
Jacobe, Heidi
中科院分区：
文献类型：
--
作者：
Condie, Daniel;Grabell, Daniel;Jacobe, Heidi
很少有研究关注儿童发病的成人硬斑病的结局。本研究的目的是比较成人和儿童发病的硬斑病患者的临床结局和健康相关的生活质量。该研究的参与者来自成人和儿童Morphea队列，包括68名儿童发病的成人Morphea和234名成人发病的Morphea患者。结果测量包括局部硬皮病皮肤评估工具（LoSCAT），体格检查结果和生活质量问卷。成人儿童发病的硬斑病较年轻，病程较长，更可能有线性亚型的硬斑。儿童期发病的患者不太可能有活动性疾病。在活动性疾病患者中，根据LoSCAT测量，儿童期发作的硬斑病患者的疾病活动性较低。儿科发病的患者有较高的疾病损害，由医生的整体评估的损害，但类似的疾病损害，由局部硬皮病皮肤损伤指数测量。儿童期发病的患者在所有指标上的生活质量评分都更好，达到统计学显著性。成人儿童发病的硬斑病与成人发病的硬斑病在亚型、疾病活动性、疾病损害和健康相关的生活质量方面不同。
Few studies have looked at outcomes of adults with pediatric-onset morphea. The objective of the present study was to compare clinical outcomes and health-related quality of life in adults with pediatric-onset morphea to those of patients with adult-onset morphea. Participants in the study were drawn from the Morphea in Adults and Children Cohort and included 68 adults with pediatric-onset morphea and 234 patients with adult-onset morphea. Outcome measures included the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT), physical exam findings, and quality of life questionnaires. Adults with pediatric-onset morphea were younger, had longer disease duration, and were more likely to have the linear subtype of morphea. Patients with pediatric-onset disease were less likely to have active disease. Among patients with active disease, those with pediatric-onset morphea had less disease activity as measured by the LoSCAT. Patients with pediatric-onset disease had higher disease damage as measured by the Physician Global Assessment of Damage, but similar disease damage as measured by the Localized Scleroderma Skin Damage Index. Patients with pediatric-onset disease had more favorable quality of life scores for all measures that reached statistical significance. Adults with pediatric-onset morphea differ from patients with adult-onset disease with respect to subtype, disease activity, disease damage, and health-related quality of life.
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DOI：
10.1111/j.1349-7006.1988.tb01549.x
发表时间：
1988-11
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Koizumi S
通讯作者：
Koizumi S
影响因子：
--
作者：
KREMER, JM;GALIVAN, J;KAMEN, B
通讯作者：
KAMEN, B
DOI：
10.1016/0006-291x(73)90949-2
发表时间：
1973-01-01
影响因子：
3.1
作者：
BAUGH, CM;KRUMDIECK, CL;NAIR, MG
通讯作者：
NAIR, MG
影响因子：
--
作者：
Becker, Mara L.;van Haandel, Leon;Leeder, J. Steven
通讯作者：
Leeder, J. Steven
影响因子：
2.9
作者：
HENDEL, J;NYFORS, A
通讯作者：
NYFORS, A