Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane.

Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane.
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DOI:
10.1083/jcb.202306126
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发表时间:
2023-08-07
期刊:
The Journal of cell biology
影响因子:
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其他
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Symeon Siniossoglou讨论了沃兹尼亚克实验室的工作,该工作表明,内核膜蛋白的瞬时SUMO化推动了有丝分裂期间核膜的扩张。真核细胞分裂涉及两个子细胞之间的染色体分离,必须与其核膜的广泛重排相协调。在本期中,Saik等人。(2023年J.细胞生物学。Https://doi.org/10.1083/jcb.202208137)表明,核内膜上的SUMO化级联增加了磷脂酸的水平,磷脂前体是关键的磷脂前体,以支持有丝分裂期间核膜扩张的需要。
Symeon Siniossoglou discusses work from the Wozniak lab, which shows that transient SUMOylation of inner nuclear membrane proteins drives expansion of the nuclear membrane during mitosis. Eukaryotic cell division involves the segregation of chromosomes between two daughter cells and must be coordinated with extensive rearrangement of their nuclear envelopes. In this issue, Saik et al. (2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137) show that a SUMOylation cascade at the inner nuclear membrane elevates the levels of phosphatidic acid, a key phospholipid precursor, to support the need for nuclear membrane expansion during mitosis.
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