Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane.
Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane.
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DOI:
10.1083/jcb.202306126
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发表时间:
2023-08-07
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影响因子:
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中科院分区:
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Symeon Siniossoglou discusses work from the Wozniak lab, which shows that transient SUMOylation of inner nuclear membrane proteins drives expansion of the nuclear membrane during mitosis. Eukaryotic cell division involves the segregation of chromosomes between two daughter cells and must be coordinated with extensive rearrangement of their nuclear envelopes. In this issue, Saik et al. (2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137) show that a SUMOylation cascade at the inner nuclear membrane elevates the levels of phosphatidic acid, a key phospholipid precursor, to support the need for nuclear membrane expansion during mitosis.
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