Structure and function of the membrane deformation AAA ATPase Vps4.

Structure and function of the membrane deformation AAA ATPase Vps4.
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膜变形AAA ATPase VPS4的结构和功能。

DOI:
10.1016/j.bbamcr.2011.08.017
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发表时间:
2012-01
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Babst M
Babst M
中科院分区:
其他
文献类型:
--
作者:
Hill CP;Babst M

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ATP酶Vps4属于I型AAA蛋白质家族。Vps4在膜变形和裂变事件中与一组称为ESCRT的蛋白质一起起作用。这些细胞功能包括内体囊泡形成、胞质分裂和病毒出芽。Vps4的高度动态四级结构及其与调节剂和辅因子网络的相互作用使得该ATP酶的分析具有挑战性。尽管如此,最近的进展,在理解细胞生物学的Vps4连同结构信息和体外研究的指导机制模型,这ATP酶。
The ATPase Vps4 belongs to the type-I AAA family of proteins. Vps4 functions together with a group of proteins referred to as ESCRTs in membrane deformation and fission events. These cellular functions include vesicle formation at the endosome, cytokinesis and viral budding. The highly dynamic quaternary structure of Vps4 and its interactions with a network of regulators and co-factors have made the analysis of this ATPase challenging. Nevertheless, recent advances in the understanding of the cell biology of Vps4 together with structural information and in vitro studies are guiding mechanistic models of this ATPase.
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