Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes.
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes.
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DOI：
10.3389/fgene.2018.00524
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发表时间：
2018
影响因子：
3.7
通讯作者：
Beucher A
中科院分区：
文献类型：
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作者：
Font-Cunill B;Arnes L;Ferrer J;Sussel L;Beucher A
分化细胞的转录程序受到细胞类型特异性转录因子和顺式调控元件相互作用的严格调控。长非编码RNA(LncRNAs)作为基因转录的额外调节因子已经出现。目前的证据表明，lncRNAs是一组非常不均匀的分子。例如，选定的lncRNAs已被证明调节顺式或反式基因的表达，尽管在大多数情况下，确切的潜在分子机制尚不清楚。最近的研究发现，大量的lncRNA在胰岛细胞中选择性表达，其中一些被证明调控β细胞的转录程序。这类胰岛中的一部分似乎通过局部顺式调控来控制β细胞特异性转录因子(TF)基因的表达。在这篇综述中，我们讨论了目前关于顺式调控lncRNA的分子机制的知识，并讨论了使用遗传扰动来定义它们的功能所涉及的挑战。然后我们讨论已知的胰岛lncRNAs的例子，它似乎对TF基因施加顺式调节。我们认为顺式调控的lncRNAs可能是糖尿病相关基因调控的分子靶点。
The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene transcription. Current evidence indicates that lncRNAs are a very heterogeneous group of molecules. For example, selected lncRNAs have been shown to regulate gene expression in cis or trans, although in most cases the precise underlying molecular mechanisms is unknown. Recent studies have uncovered a large number of lncRNAs that are selectively expressed in pancreatic islet cells, some of which were shown to regulate β cell transcriptional programs. A subset of such islet lncRNAs appears to control the expression of β cell-specific transcription factor (TF) genes by local cis-regulation. In this review, we discuss current knowledge of molecular mechanisms underlying cis-regulatory lncRNAs and discuss challenges involved in using genetic perturbations to define their function. We then discuss known examples of pancreatic islet lncRNAs that appear to exert cis-regulation of TF genes. We propose that cis-regulatory lncRNAs could represent a molecular target for modulation of diabetes-relevant genes.
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影响因子：
10.5
作者：
Arnes L;Akerman I;Balderes DA;Ferrer J;Sussel L
通讯作者：
Sussel L
影响因子：
64.8
作者：
Carrieri, Claudia;Cimatti, Laura;Gustincich, Stefano
通讯作者：
Gustincich, Stefano
影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
影响因子：
29
作者：
Akerman I;Tu Z;Beucher A;Rolando DMY;Sauty-Colace C;Benazra M;Nakic N;Yang J;Wang H;Pasquali L;Moran I;Garcia-Hurtado J;Castro N;Gonzalez-Franco R;Stewart AF;Bonner C;Piemonti L;Berney T;Groop L;Kerr-Conte J;Pattou F;Argmann C;Schadt E;Ravassard P;Ferrer J
通讯作者：
Ferrer J
影响因子：
64.8
作者：
通讯作者：
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